BTCA

CAS 81927-55-1, Cat. No EN300-6496297
Reagent for hydroxy group protection

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Benzyl 2,2,2-trichloroacetimidate (BTCA) is a reagent commonly used for the protection of hydroxyl groups as benzyl ethers under mild acidic conditions, often employing triflic acid (TfOH) as a catalyst¹. Its scope includes protecting alcohols (especially in acid-sensitive compounds), carbohydrates, amino acid derivatives, and complex natural products, where traditional base-promoted benzylation methods can cause side reactions. BTCA is a colorless, moisture-sensitive oil that is stable under dry, nonpolar solvent conditions and decomposes in polar solvents.

Synonyms: benzyl 2,2,2-trichloroacetimidate; BTCA; BnTCAI