2,3,5,6-Tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1-one

CAS 95111-49-2, Cat. No EN300-7411622
Reagent for aromatic nitration

2,3,5,6-Tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1-one

The molecule is a mild and selective nitration reagent used for mono-nitrating aromatic compounds like naphthols and phenols[1]. It offers advantages over traditional nitration methods by minimizing oxidation and regioselectivity issues[2]. The reagent is a bench-stable solid, well-soluble in most organic solvents, which makes it a desirable choice for nitration.

Synonyms: 4-Methyl-4-nitro-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one

Selected publication

  1. Direct Nitration of Anilines Using Nitrocyclohexadienones.

    Lemaire M.; Guy A.; Boutin P.; Guette J. Synthesis 1989, 1989 (10), 761–763. DOI: 10.1055/s-1989-27387

  2. Facile Synthesis of 2,3,5,6-Tetrabromo-4-Methyl-Nitrocyclohexa-2,5-Dien-1-One, a Mild Nitration Reagent.

    Arnatt C.; Zhang Y. Tetrahedron Lett 2012, 53 (13), 1592–1594. DOI: 10.1016/j.tetlet.2012.01.066

 

 

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