CAS 530-62-1, Cat. No EN300-21023
Reagent for activation of carboxylic acids


CDI is a classical reagent for the activation of carboxylic acids for the reaction with nucleophiles[1]. The reagent is white solid, and shelf-stable but is moisture sensitive and reacts with water to produce CO2. It is well soluble in THF, benzene, CHCl3, and DMF, but solvents need to be dehydrated before usage. Beyond the synthesis of esters and amides, the reagent may be used as a direct replacement for the highly toxic Phosgene in reactions with alcohols and amine.

Synonyms: N,N′-Carbonyldiimidazol, CDI

Selected publication

  1. N,N ′-Carbonyldiimidazole.

    Armstrong A.; Li W. Encyclopedia of Reagents for Organic Synthesis 2007. DOI: 10.1002/9780470842898.rc024