CAS 2179072-33-2, Cat. No EN300-6734306
Donor of F-SO2+ moiety


SuFEx-IT is click-chemistry reagent that is a much safer analog of SO2F2 gas, that offers more simple procedure and less hazard to health. Even more, SuFEx-IT possesses greater reactivity, selectivity compere to SO2F2[1]. The F-SO2+ fragment attaches to H-containing acceptor groups such as phenols and amines to give fluorosulfates and sulfoamoyl fluorides respectively with good yields[2], [3].

Synonyms: 1-(fluorosulfonyl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate, Fluorosulfuryl imidazolium salt

Selected publication

  1. A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope.

    Guo T.; Meng G.; Zhan X.; Yang Q.; Ma T.; Xu L.; Sharpless K. B.; Dong J. A Angewandte Chemie International Edition 2018, 57 (10), 2605–2610. DOI: 10.1002/anie.201712429

  2. Modular Click Chemistry Libraries for Functional Screens Using a Diazotizing Reagent.

    Meng G.; Guo T.; Ma T.; Zhang J.; Shen Y.; Sharpless K. B.; Dong J. Nature 2019, 574 (7776), 86–89. DOI: 10.1038/s41586-019-1589-1

  3. Emerging Utility of Fluorosulfate Chemical Probes.

    Jones L. H. ACS Med Chem Lett 2018, 9 (7), 584–586. DOI: 10.1021/acsmedchemlett.8b00276