Trifluoroethanol tosylate

CAS 433-06-7, Cat. No EN300-30885
Reagent for etherification by CH2CF3 of aromatic alcohols

2,2,2-Trifluoroethyl p-toluenesulfonate

2,2,2-Trifluoroethyl p-toluenesulfonate is a widely used reagent for the efficient etherification of aromatic alcohols with the -CH2CF3 group. It exists as a solid white powder with a relatively low melting point, and it is important to handle it carefully as it is moisture-sensitive. The reagent has selectivity to aromatic alcohols, and ignore other functional group such as ketones. The reaction of etherification with this reagent is a procession simple and has a good yield. Additionally, this reagent serves as a valuable precursor for essential building blocks used in the difluoroethenylation of arenes through coupling reaction.

Synonyms: 2,2,2-Trifluoroethyl 4-methylbenzenesulfonate, 2,2,2-Trifluoroethyl tosylate, 2,2,2-Trifluoroethyl p-toluenesulfonate