Building Blocks Catalog

300 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

1B novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Compound Libraries

Over 60 pre-plated libraries in stock

Fast delivery

Library Synthesis

48B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

MedChem Highlights

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2024

Heterocyclic scaffolds
gem-Difluorinated Amines
Morpholine Bioisosteres
Deuterium-containing BBs
Ideal Bioisostere
Piperidine Bioisostere
Piperazine Bioisosteres
7- and 8-Membered Rings
Cubanes

Recent News

  • 11 April 2024   Press Release

    Metrion Biosciences enhances High Throughput Screening services with access ...

    Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.

  • 27 March 2024   Press Release

    Enamine Announces Expansion of Its Library Synthesis Capabilities

    March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.

  • 01 March 2024   News

    Enamine and Genez International Announce Strategic Collaboration to Launch ...

    We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.

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Tailored towards your needs!

Discover new horizons with Enamine Computer-Aided Drug Design services. Partner with our skilled team, experts in crafting specialized workflows using cutting-edge chemoinformatics and modeling tools. We believe that teamwork among chemists, biologists, and chemoinformaticians is key to success. That s why our departments work closely together to improve the efficiency of your drug discovery project significantly. Through a comprehensive selection of approaches and seasoned professionals, our CADD platform aims to be an all-encompassing solution for your scientific challenges.

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What our tools?

Target Modeling

Molecular Dynamics (MD) simulation

  • Demonstration of the evolution of the biological systems in time
  • Investigation of target-drug interaction in depth
  • Validation of ligands selected during virtual screening
  • Estimation protein-ligand binding energy

Homology Modeling

  • 3D-structure prediction for unresolved targets
  • Structure repairing
  • Mutant modelling

Target structure analysis

  • Potential binding site searching
  • Active residue estimations
  • Mutagenesis data analysis

Ligand Searching

Analogs Searching

  • 2D searching (Morgan Fingerprints,ECFPs, etc.)
  • 3D searching (Electroshape, USRCAT, E3FP, etc.)
  • Diversification
  • Search of BM scaffolds, substructure search, synthons search

3D - QSAR modelling

  • Estimation of physicochemical properties and biological activity
  • Prediction of the full activity profile of given compounds against a panel of different biological targets
  • Establishment of structure-activity relationships

Hit-2-Lead integrated projects support

  • Evaluation of synthetic feasibility and screening results analysis
  • Re-scaffolding
  • Bioisosteric replacements

Virtual screening

  • Molecular docking
  • 3D Pharmacophore search

We use a balanced approach employing different methods complementing each other

Why Enamine CADD?

Validity
Enamine has the world’s largest collection of small molecules in stock adding 300,000 new compounds each year. Virtual screening databases are continuously updated with products of synthesis using new reactions and chemotypes.

Tailored Approach
We work closely with our clients to build an optimal problem-solving algorithm, based on our strong knowledge and experience in this field.

Experienced Team of Experts
Our CADD team consists of highly skilled experts: 4 PhDs and 3 MS graduates in the fields of chemistry, biology, and computational sciences.

Successful Collaborations and Research
We've already identified low-micromolar hit compounds for over 30 targets.

Handling of Massive Chemical Spaces
We can efficiently manage and process ultra-large compound libraries, such as REAL Database (exceeding 30 billion molecules) and beyond.

Seamless Chemistry and Biology Team Collaboration
Our chemistry and biology experts work closely together to critically assess results and offer recommendations for improvement, ensuring a unified approach to achieving the objectives of your project.

Custom Compound Design through Virtual Techniques
Additionally, we have the capability of employing virtual design of custom compounds. This encompasses techniques such as enumeration, scaffold hopping, and bioisosteric replacement, all executed with a focus on ensuring that synthesis remains feasible.

Contact Us

Discover the depth of our experience and success through specific case studies here.

Selected publications

  1. Creation of targeted compound libraries based on 3D shape recognition.
    Mol Divers 2022, 27, 939–949. DOI: 10.1007/s11030-022-10447-z
  2. Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo.
    J of Extracellular Vesicle 2020, 10. DOI: 10.1002/jev2.12039
  3. Modelling of an autonomous Nav1.5 channel system as a part of in silico pharmacology study.
    J Mol Model 2021, 27. DOI: 10.1007/s00894-021-04799-w
  4. Integrated workflow for the identification of new GABA positive allosteric modulators based on the in silico screening with further in vitro validation.
    Molecular Informatics 2023. DOI: 10.1002/minf.202300156 Case study using Enamine’s stock chemical space.

Compound Library Management

Reformatting and storage of the compound libraries require not only an exorbitant investment in liquid-handling lab and low-temperature storage facility, but also in-depth expertise in compound management, organizing workflows and logistics. We are happy to share with you our skills and capabilities to cost-efficiently support your discovery programs with storing purchased or synthesized compound libraries at Enamine and supply them to your labs in most suitable plated format.

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Compound plating

We can work with any plate format, from 96- to 1536-well plates, and provide them in practically any layout and scenario including:

  • Multiple copies
  • Assay-ready plates using nanolitre-scale acoustic dispensing
  • Dose response curve (DRC) plates
  • Flexible compound cherry-picking
  • Compound pooling

Library storage

We can store your library either acquired from our extensive Compound Library catalog or sent to us from any location in the world in our cold room at -18°C. We will provide a copy of this library to a screening lab of your choice in just-in-time mode. This may be our HTS lab at Bienta or any other CRO you collaborate with.

Equipment list

  • Beckman Biomek i7 and i5 Automated Workstations including Span-8, 96- and 384-channel heads
  • Beckman Echo 550 / 650 / 655 Series Acoustic Liquid Handlers
  • Tecan Freedom EVO (Liquid & Air)
  • Agilent Bravo Automated Liquid Handling Platform with 384- or 96-channel heads
  • Dynamic Devices Lynx Liquid Handling Platform with 384- or 96-channel heads
  • Hamilton LabElite DeCapper
  • Agilent PlateLoc Thermal Microplate Sealer with optional sealing under argon atmosphere
  • Micronic Side Barcode Readers
  • Thermo Scientific™ VisionMate™ High Speed Barcode Reader
  • BioMicroLab SampleScan Mini
  • BioMicroLab Volume Check System VC384

To ensure accuracy for the plates formatting all the equipment is undergoing regular service maintenance checks.

Accumulating the chemical knowledge and experience since 1991 helped Enamine to shape itself into a reliable partner in comprehensive research projects and services.

Library Synthesis

Services ranging from the synthesis of composed chemical libraries to the assistance in designing and developing a library from a scratch.

Custom Synthesis

Applying the top-level chemical experience of Enamine’s chemistry team for implementation of the complex, daring and cutting-edge scientific ideas in synthesis.

FTE Support

  • Leveraging our Building Block catalog advantage and vast expertise, our chemists can accelerate and enhance on-going discovery projects.
  • Leveraging our Building Block catalog advantage and vast expertise for accelerating your discovery projects.

CADD Full Assistance

Experience full-stack support provided by Enamine's CADD team in accelerating every phase of your drug discovery process: from target investigation and modeling to hit identification seamlessly transitioning into lead optimization, harness the power of our cutting-edge computational methodologies for impeccably refined outcomes.

Biology

Integrated end-to-end CRO services, covering all aspects of early drug discovery from the drug idea through Hit Finding and Lead Optimization stages to Formulation Studies.

Hit Follow up support

Providing analogs from stock collection, REAL database, individual design of compounds for hit follow-up process that can be strengthened by Enamine biology team.

Compound Library Management

The success of a hit finding campaign heavily depends on quality of screening library and hit confirmation process. We offer seamless support in following-up the hits identified after screening of our Compound Libraries.

  • Hit Confirmation: dry samples resupplied from the same batch, QC check, HPLC repurification, chiral resolution, impurities identification.
  • Analogs: search within over 4.2M stock Screening Collection, REAL Database and REAL Space. Enumeration of new hit follow-up libraries.
  • Resynthesis: typically within 3 weeks following in-house synthesis protocols.

 

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If you purchase our screening library, you can fully benefit from our Compound Management services. We offer storage of the libraries in a special low-temperature facility and delivery of plate copies for screening or hit confirmation on your order.

 

Hit Confirmation

  • Resupply from the same batch
  • Quality control using advanced techniques
  • HPLC purification, chiral separation
  • Resynthesis and structure confirmation

Hit Expansion

  • Analogs in Screening Collection, REAL Database and REAL Space
  • Follow-up libraries design and enumeration of new molecules
  • In silico screening services: Pharmacophore modeling and docking calculation, MD simulations.

Hit to Lead

  • FTE-based Chemistry support
  • Broad ADME panel
  • PK studies

We offer cost-effective chemistry support to any medchem-related projects including synthesis of sophisticated individual compound and unchallenged parallel synthesis of small focused libraries besides conventional wet chemistry. Enamine is a non-classic CRO, rather a chemistry research organization. Having the largest proportion of its business in compound catalog sales, the company has accumulated over the years at its research site in Kyiv the world’s largest collection of building blocks. You can access this powerful resource directly at Enamine when outsourcing your chemical FTE’s to us. This will allow you to:

  • Decrease turnaround time by having same day supply to your FTE labs
  • Access unique compounds available exclusively from Enamine
  • Save on costs

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Our proven high potential to accelerate and enhance drug discovery projects has been recognized by a recently drastically growing number of clients – from academic labs to big pharma companies viaSME’s. The number of chemical FTE’s outsourced to Enamine has doubled since 2019. Currently only 1/3 of our chemists are engaged in FTE collaborations and we can easily expand our service branch by relocating additional chemists from non-exclusive synthesis for our public catalogs.

Enamine has proven to be the utmost professional in conducting their service. The number, quality and quantity of synthesized compounds are unchanged and entirely satisfying.

Dr. Hannelore Meyer

Technical University Munich

May 2023

We value the output and responsiveness of the Enamine team, helping us to achieve our demanding milestones. It is stunning to see how well Enamine has been able to keep pace after February 2022.

Dr. Sven Weiler

Vice President of Medicinal Chemistry, Endogena

May 2023

FTE chemistry support

Skillful chemists

Enamine is a global leader in synthetic innovation in medicinal chemistry. We have over 650 skillful chemists with scientific expertise in various fields of chemistry widely documented in the peer-reviewed scientific journals. Our chemists have in-depth experience in a wide number of unique chemical techniques such as fluorination with SF4, photochemistry in flow, electrochemistry, high-pressure hydrogenation etc., which are well validated at Enamine and are scarcely available at other CRO’s.

Building Blocks

Our FTE rate includes free-of-charge access to most of our building blocks and the rest is offered with a sizeable discount. Our clients benefit from our enormous experience in building block synthesis. Enamine’s collection of make-on-demand “MADE” building blocks provides an important source of ideas and inspiration.

Parallel synthesis capabilities

We can use parallel synthesis for more than 35 different reactions including photochemistry. Based on the deep knowledge of our building blocks and on their reactivity we have developed predictive models which can maximize success rate in synthesis of compound libraries. Read more…

Molecular modeling

If needed Enamine Molecular modeling group can support the project with virtual screening, pharmacophore modeling and other CADD services.

Flexible arrangement

In contrast to classical CRO’s, the number of FTE’s at Enamine can be amended on a ultra-short notice, should it be to increase or decrease the size of a team.

ADMET/PK tests and HTS

Bienta, the biological department of Enamine (www.bienta.net), can deploy state-of-the-art support to medchem collaborations by providing ADMET and Pharmacokinetics tests including animal studies. If a new hit-finding campaign is required, Bienta can offer HTS using Enamine’s significant diverse screening libraries or any customizable set from targeted and diverse libraries pools available at Enamine, which are totaling over 4.2M compounds. Read more…

All these features and more make Enamine a partner of first choice for different types of FTE-projects including:

  • Synthesis of hit-finding libraries, analog preparation;
  • Scaffold decoration using diverse capping agents;
  • Singleton synthesis, Hit-to-lead optimization, scaffold-hopping;
  • Synthesis of Building-Blocks / scaffolds including scale-up validation;
  • Feasibility studies.

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