Building Blocks Catalog

284 Thousand compounds in stock

Original and unique

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Building Blocks

210 Million novel building blocks

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Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

31B Billion REAL compounds and

Custom Library Synthesis

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On site access to all Enamine stock BB’s

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from October 2022

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Bioactive Library

Collection of referred small molecules with carefully collected activity data

2 320 compounds

To address continuously growing interested to Drug Repurposing we designed and carefully collected a Bioactive Reference Collection of over 2 300 compounds with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs and steroids.

Request

Represented collection of carefully selected compounds includes 1 040 FDA approved drugs, as well as “tool compounds” with validated biological activity, active metabolites/prodrugs, and drug candidates that are currently undergoing clinical trials.

Ready-to-use, fully referred, alternative for compound screening.

Any compound from BRC collection can be ordered individually as focused sets: target-based or by therapeutic area.

Proven and reliable

  • Stringent quality control using most advanced methods.
  • Synthetic chemistry capacity with professionals in organic chemistry experienced in diverse synthetic methods and techniques.
  • Drugs synthesis and their functional modifications for target identification and other purposes.

Distribution of compounds by therapeutic area

Related products & services

Target identification toolbox

Additionally we provide broad functionalization of Drugs and relative actives with covalent warheads, biotin or/and dye-linking, PED-derivatization and other modifications. Versatile chemistry and the largest stock of valuable reagents enables Enamine to produce new functionalization of well-known drugs.

We combined most diverse approaches and possible structural modifications to achieve most complete representation of our Target identification tools.

We offer over 60 ready-to-deliver pre-plated compound libraries in a variety of custom formats. Our well-equipped liquid handling department will make a library copy in any convenient for you project format.

Diversity Libraries

Product name
Size
Description
Download file

Format/Size

460 160 compounds

Description

The largest diversity library with high MedChem tractability

Download file

&nsbp;

Size

50 240 compounds

Descriptions

Top-quality diverse library of recently synthesized compounds

Download file

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Size

10 240 compounds

Descriptions

High-quality diverse library of latest compounds

Download file

&nsbp;

Size

11 200 compounds

Descriptions

Diverse Covalent Library with most demanded warhead types

Download file

&nsbp;

Size

5 760 compounds

Descriptions

Special diversity library created for Phenotypic Screens

Download file

&nsbp;

PAINS Library

PAINS-320

Size

320 compounds

Descriptions

Special diverse selection of frequent hitters

Download file

&nsbp;

Covalent Libraries

Product name
Size
Descriptions
Download file

Size

11 200 compounds

Descriptions

Diverse Covalent Library with most demanded warhead types

Download file

&nsbp;

Size

12 160 compounds

Descriptions

Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

Download file

&nsbp;

Size

2 640 compounds

Descriptions

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

Download file

&nsbp;

Size

7 360 fragments

Descriptions

Diverse covalent warheads with balanced reactivity

Download file

&nsbp;

Size

3 200 fragments

Descriptions

Library of Cys-specific covalent electrophilic binders

Download file

&nsbp;

Size

1 600 fragments

Descriptions

Special selection of Serine focused irreversible binders

Download file

&nsbp;

Size

1 600 fragments

Descriptions

A unique set of 1 600 Lys specific binders

Download file

&nsbp;

Size

960 fragments

Descriptions

Characterized by a new HTS thiol-reactivity assay

Download file

&nsbp;

Acrylamide Library

sACR-4080

Size

4 080 compounds

Descriptions

Diverse screening Acrylamides pre-plated at 10 mM concentration

Download file

&nsbp;

Size

2 240 compounds

Descriptions

Representative selection of fragment Acrylamides pre-plated at 100 mM stock concentration

Download file

&nsbp;

Chloroacetamides

sCLA-1200

Size

1 200 compounds

Descriptions

Library of diverse HTS-size chloroacetamides pre-plated at 10 mM concentration

Download file

&nsbp;

Size

1 360 compounds

Descriptions

Diverse strict Ro3 compliant chloroacetamides plated at 100 mM stock concentartion

Download file

&nsbp;

Size

640 compounds

Descriptions

Representative selection of N-, O-linked and Aryl sulfonyl fluorides within fragment space

Download file

&nsbp;

Targeted Libraries

Product name
Size
Descriptions
Download file

Size

10 240 compounds

Descriptions

Library of compounds intended for use in agro/crop science

Download file

&nsbp;

Size

14 400 compounds

Descriptions

Designed for discovery of novel allosteric ligands

Download file

&nsbp;

Size

4 800 compounds

Descriptions

Carefully selected molecules via docking and visual evaluation

Download file

&nsbp;

Size

3 200 compounds

Descriptions

Designed for discovery of new Nucleoside-like antivirals

Download file

&nsbp;

Size

10 560 compounds

Descriptions

Designed for discovery of new Voltage-gated calcium channel blockers

Download file

&nsbp;

CNS Library

CNS-47

Size

47 360 compounds

Descriptions

Library of novel small molecules with high CNS MPO scores

Download file

&nsbp;

Size

16 800 compounds

Descriptions

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

Download file

&nsbp;

Size

2 470 compounds

Descriptions

Specially synthesized set of compounds able to mimic glycosides and their interaction with proteins

Download file

&nsbp;

GPCR Library

GPR-54

Size

54 080 compounds

Descriptions

Designed for discovery of new GPCR ligands

Download file

&nsbp;

Size

24 000 compounds

Descriptions

Designed for discovery of novel kinase ATP pocket binders

Download file

&nsbp;

Size

1 003 compounds

Descriptions

IDO focused library designed by a combination of structure- and ligand-based methods

Download file

&nsbp;

Size

36 800 compounds

Descriptions

Designed for discovery of new Ion Channels ligands

Download file

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Kinase Library

KNS-64960

Size

64 960 compounds

Descriptions

Designed for discovery of novel protein kinase inhibitors

Download file

&nsbp;

Size

5 440 compounds

Descriptions

A sub-library of Enamine’s GPCR Library designed for discovery of novel lipid GPCR ligands

Download file

&nsbp;

Size

2 468 compounds

Descriptions

A set of compounds focused on targeting molecular chaperones

Download file

&nsbp;

Size

320 compounds

Descriptions

Small library of specially synthesized compounds

Download file

&nsbp;

Size

1 920 compounds

Descriptions

Sublibrary of PPI-40

Download file

&nsbp;

Size

8 960 compounds

Descriptions

Selected molecules able to mimic common protein motifs

Download file

&nsbp;

Size

40 640 compounds

Descriptions

Designed for discovery of novel PPI inhibitors

Download file

&nsbp;

RNA Library

RNA-15520

Size

15 520 compounds

Descriptions

Library of compounds capable of binding to RNA

Download file

&nsbp;

Size

12 160 compounds

Descriptions

Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

Download file

&nsbp;

Size

5 440 compounds

Descriptions

Designed for discovery of new Nav1.7 channel blockers

Download file

&nsbp;

Bioactive Libraries

Product name
Size
Descriptions
Download file

CLOUD

CLOUD-293

Size

293 compounds

Description

Represents the diversity of structures and molecular targets of all FDA-approved chemical entities (Nat Chem Biol 13 (2017), 771–778)

Download file

&nsbp;

Size

1 040 compounds

Description

Most relevant selection of drugs in one formulation/no duplicates. Contains WHO List of Essential Medicines including Lapatinib and latest approved drugs such as Tivozanib, etc.

Download file

&nsbp;

Size

2 320 compounds

Descriptions

Actives with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs, steroids and molecular glues.

Download file

&nsbp;

Size

5 760 compounds

Description

Library of cell penetrated compounds and their closest analogs. Covers diverse therapeutic areas from antitumor, neurology and antibacterial to aging diseases.

Download file

&nsbp;

PAINS Library

PAINS-320

Size

320 compounds

Description

Frequent hitters with most diverse scaffold selection – from small hydroquinone and other covalent modifiers to polyfluorinated highly lipophilic molecules and dyes.

Download file

&nsbp;

Fragment Libraries

Product name
Size
Description
Download file

Size

320 compounds

Description

Elaborated tool for initial screen

Download file

&nsbp;

Size

1 920 compounds

Description

Fragments of high MedChem tractability

Download file

&nsbp;

Size

860 compounds

Description

Designed for easy and rapid follow-up synthesis

Download file

&nsbp;

MiniFrag Library

MiniFrag-80

Size

80 compounds

Description

Guiding optimisation of fragment-derived lead compounds

Download file

&nsbp;

Size

7 360 fragments

Description

Diverse covalent warheads with balanced reactivity

Download file

&nsbp;

Size

1 000 compounds

Description

Specially designed for 19F NMR ligand-based screening

Download file

&nsbp;

Size

640 fragments

Description

Designed for easy and efficient exploration of novel protein targets

Download file

&nsbp;

Size

4 160 compounds

Description

Source of biologically validated starting points

Download file

&nsbp;

Size

1 200 compounds

Description

Unique 3D diversity among shaped molecules

Download file

&nsbp;

Size

3 600 compounds

Description

Fragments able to mimic protein structural motifs and hot-spot residues

Download file

&nsbp;

Size

1 500 compounds

Description

Fragments for easy-to-analyse protein-ligand interaction

Download file

&nsbp;

Size

4 000 compounds

Description

Designed for specific protein targets and sensible onset

Download file

&nsbp;

Size

960 fragments

Description

Characterized by a new HTS thiol-reactivity assay

Download file

&nsbp;

PAINS Library

Special diverse selection of frequent hitters

320 compounds

Pan-Assay Interference Compounds (PAINS) are the most recognized filters among medicinal chemists. Since first publication in 2010 by John Bell these filters have become industry standard in Drug Discovery. While carefully removing all PAINS-related compounds from Enamine libraries we realized that these compounds can be very useful in HTS assay set-up & validation.

Request

Special diversity set of PAINS available for prompt delivery in various plated formats including the most popular listed below:

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

PAINS-320-10-Y-10

Compounds

320
1 plate

Amount

10 μL of 10 mM DMSO solutions

Plates and formats

384-well acoustic plates, Labcyte #PP-0200,
last two columns empty;

Price

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Catalog No.

PAINS-320-50-Y-10

Compounds

320
1 plate

Amount

50 μL of 10 mM DMSO solutions

Plates and formats

384-well plates, Greiner #784201,
1, 2 and 23, 24 columns empty;
320 compounds per plate

Price

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Catalog No.

PAINS-320-100-X-10

Compounds

320
4 plates

Amount

100 μL of 10 mM DMSO solutions

Plates and formats

96-well plates, Greiner #65021,
1 and 12 columns empty;
80 compounds per plate

Price

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Catalog No.

PAINS-320

Compounds

320

Amount

Custom

Plates and formats

Any custom format

Price

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Library design

The design is based on substructural motifs of known PAINS compounds. We used originally reported PAINS filters to identify a set of 75k+ in-stock compounds. This set was clustered using fingerprint-based approach and Tanimoto similarity distance calculations. The most populated clusters with at least 5 compounds were extracted and one representative example was selected from each cluster resulting in a library of 320 compounds. The library of most diverse 320 PAINS is available in plate format for your convenience. Examples are given below.

Key features

  • Represents the most common false positives
  • Substructure & scaffold diversity
  • All compounds suitable for storage as DMSO solutions

Example of structures and their specific PAINS filters

Diversity Libraries

Product name
Description
Download
Price

CLOUD

CLOUD-293

293 compounds

Description

Represents the diversity of structures and molecular targets of all FDA-approved chemical entities (Nat Chem Biol 13 (2017), 771–778)

Download file

Price

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FDA approved drugs

FAD-1040

1 040 compounds

Description

Most relevant selection of drugs in one formulation/no duplicates. Contains WHO List of Essential Medicines including Lapatinib and latest approved drugs such as Tivozanib, etc.

Download file

Price

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Bioactive Library

BRL-2320

2 320 compounds

Description

Actives with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs, steroids and molecular glues.

Download file

Price

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Phenotypic Screening Library

PSL-5760

5 760 compounds

Description

Library of cell penetrated compounds and their closest analogs. Covers diverse therapeutic areas from antitumor, neurology and antibacterial to aging diseases.

Download file

Price

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PAINS Library

PAINS-320

320 compounds

Description

Frequent hitters with most diverse scaffold selection – from small hydroquinone and other covalent modifiers to polyfluorinated highly lipophilic molecules and dyes.

Download file

Price

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Focused Sets

Target / Therapeutic Area
Description
Download
Price

Angiogenesis

184 compounds

Description

Angiogenesis related ligands targeting FLT3, DYRK1A, Collagenase 3, GAK, Bcr-Abl, BTK, EGFR etc.

Download file

Price

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Apoptosis

38 compounds

Description

Apoptosis related ligands targeting Mdm2 Mcl-1 IAP Caspase Modulator I, Caspase 3 and Caspase 6, Bcl-2, p53, TNF-alpha.

Download file

Price

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Cancer Immunology

390 compounds

Description

Molecules used for immune-oncology research targeting P2X3 receptor MAG lipase, PI3 kinase and P2Y12.

Download file

Price

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Cell Cycle

94 compounds

Description

Сell cycle related compounds, e.g. LDC000067 CDK12-In-2 and Palbociclib selective and pan-CDK inhibitors, ROCK, mTOR and Aurora kinase inhibitors.

Download file

Price

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Epigenetics

158 compounds

Description

Epigenetics related compounds targeting HDACs, HMT, JMJD, DNMT, Bromodomains, i KDM5 inhibitors and Sirtuin.

Download file

Price

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GPCRs

738 compounds

Description

Bioactive GPCR-targeted molecules, including GPCR inhibitors, agonists, and allosteric modulators. Library represents actives against 195 unique GPCR targets.

Download file

Price

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Growth Factors Cytokines

130 compounds

Description

Growth factors and cytokines ligands, including Ceritinib ALK inhibitor, Lucitanib VEGFR and FGFR inhibitor, MSX-127 CXCR4 antagonist, Eltrombopag Thrombopoietin receptor agonist etc.

Download file

Price

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Ion Channels

300 compounds

Description

Ligands with annotated activity against 6 ion channel families and 105 unique targets. The library covers major applications typical for ion channel: cardiovascular regulation, neuroscience, immune response regulation.

Download file

Price

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JAK-STAT

104 compounds

Description

JAK-STAT signalling targeted molecules, including Pazopanib multi-TK inhibitor, LY294002 TPK inhibitor, PF06700841 JAK1 inhibitor, SH-4-54 STAT3 inhibitor and other related actives.

Download file

Price

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Kinases

366 compounds

Description

Kinase binders, including approved drugs Imatinib, covalent Ibrutinib, Dasatinib and highly active inhibitors of most important kinases such as RAF, MAPK, BTK and many other.

Download file

Price

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Membrane Receptors

745 compounds

Description

Membrane receptors ligands, including Risperidone (5-HT2 receptor blocker, D2 receptor antagonist), VU0071063 (ATP-dependent potassium channel activator), CU-T12-9 (TLR1/2 antagonist), LY354740 (mGlu2/3 receptor agonist).

Download file

Price

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Nuclear Hormone Receptors

160 compounds

Description

Nuclear receptor ligands with referenced activity against 368 unique molecular targets, including agonists Dienogest, antagonists Darolutamide, inverse antagonists GSK805.

Download file

Price

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Protease Inhibitors

175 compounds

Description

High activity ligands against 104 human and pathogenic proteases, including Saxagliptin, anti-diabetic type 2 drug, Mpro SARS-CoV-2 inhibitors, Atazanavir HIV-1 protease inhibitor etc.

Download file

Price

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Signal Transduction

254 compounds

Description

Signal transduction related ligands, including Selatinib EGFR/HER-2 inhibitor, XAV-939 Tankyrase1/2 inhibitor, STING agonist-1 G10, Fedratinib broad spectrum kinase inhibitor etc.

Download file

Price

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Transporters

169 compounds

Description

Molecules with annotated activity against 12 transporter families and 82 unique targets, including Paroxetine (serotonin reuptake inhibitor), ML-352 (choline transporter 1 inhibitor, AR- C155858 (MCT1 and MCT2 inhibitor, GABA receptor ligands etc.

Download file

Price

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Fully Functionalized Probe Library

Designed for easy and efficient exploration of novel protein targets

640 compounds

Fully functionalized probes are designed to speed up and simplify early stages of drug development. Introduction of the diazirine photocrosslinking moiety along with the presence of functional acetylene group allow screening of compounds directly in cells. Originally described in the Cell paper by Ben Cravatt this approach has been adopted by other research groups to a number of successful project, including recently reported by GSK researchers ‘direct-to-biology’ high-throughput chemistry screening platform.

Request

Enamine currently has almost 6 000 fully functionalized compounds in stock and over 284k molecules in REAL Database.

The most diverse compounds have been selected and sorted out into a small library, which has been pre-plated for most convenient and fast delivery to our clients.

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

FFP-640-10-Y-20

Compounds

640
2 plates

Amount

10 µL of 20 mM DMSO solutions

Plates and formats

384-well echo plates Labcyte Cat. No PP-0200,
first two and last two columns empty,
320 compounds per plate

Price

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Catalog No.

FFP-640-50-Y-10

Compounds

640
2 plates

Amount

50 µL of 10 mM DMSO stock solutions

Plates and formats

384-well plates Greiner Cat. No. 781270,
1,2 & 23,24 columns empty,
320 compounds per plate

Price

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Catalog No.

FFP-640-100-Y-10

Compounds

640
8 plates

Amount

100 µL of 10 mM DMSO stock solutions

Plates and formats

96-well plates, Greiner Cat. No 650201, round (U) bottom,
1 & 12 columns empty,
80 compounds per plate

Price

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Catalog No.

FFP-640

Compounds

640

Amount

Custom

Plates and formats

Any custom format

Price

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Key features

  • Discovery of novel tractable protein targets
  • Identification of the binding site of the POI
  • Screening directly in cells
  • Easy hit confirmation via LC-MS
  • Next generation libraries can be rapidly synthesized through parallel chemistry

We refined our parallel chemistry protocols to synthesize photoaffinity labelled compounds, allowing our clients to rapidly access follow-up libraries based on the initial screening results.

Fully functionalized library has been designed based on the fragments with experimentally confirmed solubility in aqueous PBS at 1 mM concentration. In addition, we try to cover as much structural diversity as possible to have a different chemotypes and pharmacophores within a limited number of compounds.

Examples of the molecules in the library

Molecular Properties

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