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Reach out to new chemical space breaking the availability bias:
14 000 000 000 molecules and beyond

REAL compounds

NEWS

Feb 20, 2020

Feb 20, 2020

New chemotypes from virtual libraries: screening of Enamine REAL Database reveals in vivo hits

Melatonin (MT) receptors are established drug targets for aligning circadian phase in disorders of sleep and depression. But there are only a few in vivo hits reported to date. Enamine scientists along with the scientists from UCSF, UNC, USC, and other institutions participated in the research study aimed to fill the gap in therapeutics of these receptors. Read More >

Ref.: Nature 2020, in press

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

NEWS

Dec 12, 2019

Dec 12, 2019

New RNA targeted library has been created!

“The number of targets, the number of diseases that one could go after by targeting RNA, is almost unimaginable,” says Matt Disney, a chemist at the Scripps Research Institute.

In response to growing interest and recent advancements in targeting RNA our experts designed dedicated library of small molecules predicted to bind to RNA targets. In contrast to the classical protein targets and disease treatment, drugging RNA reveals absolutely new way to treat and prevent different disorders.

Our freshly-made library is ready for fast shipment within a week in various custom formats.

RNA Library contains 8 960 compounds. Read more>>

120 000 Fragment compounds
including 10 000 covalent binders

Fragments

NEWS

June 25, 2019

June 25, 2019

Enamine’s covalent fragments
produce potent and unique hits

In a recent JACS paper several academic groups collaborated on discovery of novel covalent inhibitors using a library of 993 acrylamides and chloroacetamides sourced from Enamine’s covalent fragment collection. The design was focusing on mild electrophiles that were supposed to overcome the selectivity challenge. The library was characterized by a new high-throughput thiol-reactivity assay and screened against 10 cysteine-containing proteins. Potent and unique primary hits have been found in the majority (7 out of 10) of cases.

A refined library used in the research with a few frequent hitters and excessively reactive fragments removed is available from Enamine on request >

Ref.: J. Am. Chem. Soc. 2019, 141, 8951−8968

The world’s largest collection of building blocks in stock:
184 345 and counting

New Building Blocks

A broad test panel to support lead discovery
Integrated projects or a-la-carte service

ADME/T & in-vivo PK

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from January 2020

Recent News

  • 20 February 2020   News

    New chemotypes from virtual libraries: screening of Enamine REAL ...

    Melatonin (MT) receptors are established drug targets for aligning circadian phase in disorders of sleep and depression. But there are only a few in vivo hits reported to date. Enamine scientists along with the scientists from UCSF, UNC, USC, and other institutions participated in the research study aimed to fill the gap in therapeutics of these receptors.

  • 19 November 2019   Press Releases

    Optibrium collaborates with Enamine and BioSolveIT to add REAL ...

    Optibrium™, BioSolveIT™ and Enamine™ today announce a three-way collaboration enabling efficient search of Enamine’s REAL Space directly from within Optibrium’s StarDrop™ software. This extension to StarDrop is powered by BioSolveIT’s proprietary Feature Trees (FTrees) technology, to search a gigantic chemical space of over 11 billion readily accessible compounds and identify novel compounds that are similar to a query structure of interest. The resulting chemical structures and data are pre-formatted and ready to evaluate using StarDrop’s comprehensive suite of integrated software for small molecule design, optimisation and data analysis.

    Read press release

  • 05 November 2019   Press Releases

    Cyclica Collaborates With Enamine to Use REAL Technology in ...

    Cyclica, Inc. announced a collaboration with Enamine Ltd. to explore its huge readily accessible chemical space using Cyclica’s state-of-the-art AI-driven Ligand Design™ platform. The companies aim to empower Cyclica’s patented, evolutionary algorithm with new design options based on the 73,000 Enamine’s in-stock building blocks and 171 thoroughly validated synthesis procedures. The joint effort is expected to enable Cyclica’s Ligand Design™ to identify novel molecules with desired polypharmacological properties out of over 11 billion REAL™ (readily accessible) compounds. At least 80% of these compounds will be synthesized by Enamine within only 3-4 weeks.

    Read press release

Upcoming events

Enamine takes an active part in the industry’s life participating in the leading international conferences, symposiums, and other events. We will be happy to meet with you, exchange opinions on the latest developments and discuss current projects and future business opportunities. For more information please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it.

2017 year

Date & Venue Event Presence
March 5 – 7
Vienna, Austria
Fragments 2017
6th RSC-BMCS Fragment-based Drug Discovery meeting
TBC

 

2016 year

Date & Venue Event Presence
November 30 – December 1
Lille, France 
Biofit 2016  Delegate 
November 28 – 29
Didcot, UK
Future of Fragments Symposium Sponsoring,
Delegate 
October 25 – 27
Berlin, Germany
12th Global Conference Intelligent Compound Libraries Sponsoring,
Presentation,
Delegate
October 9 – 12
Boston, MA, USA
FBLD 2016
Fragment-based Lead Discovery Conference 2016
TBC
September 28 – 30
Autrans, France
École Thématique de Criblage 2016 Sponsoring
September 11 – 15
Seville, Spain
6th EuCheMS Chemistry Congress Delegate
August 31 –
September 3

Heidelberg, Germany
Chemical Biology 2016 Sponsoring
August 28 –
September 1

Manchester, UK
EFMC-ISMC 2016 Booth #11
August 7 – 12
Kyiv, Ukraine
18th European Symposium on Fluorine Chemistry Organiser
July 12 – 15
Melbourne, Australia 
2nd Fragment Based Drug Discovery Down Under Meeting
(FBDD-DU)
 
Sponsoring 
July 6 – 8
Caen, France
RICT: Interfacing Chemical Biology and Drug Discovery Booth #14
June 26 – 29
Chicago, Il, USA
National Medicinal Chemistry Symposium (NMCS) TBC
June 13 – 15
Verona, Italy
6th RSC / SCI symposium on GPCRs in Medicinal Chemistry TBC
June 2 – 3
Oxford, UK
Drug discovery: creating a new ecosystem Sponsoring 
May 16 – 17
Nottingham, UK
Kinase 2016: Next Generation Inhibitors Sponsoring,
delegate
May 10 – 11
Cambridge, UK
High Content & Phenotypic Screening 2016 (SelectBio) Sponsoring,
delegate
April 21
Hatfield, UK
27th symposium on Medicinal Chemistry in Eastern England Sponsoring
April 19 – 22
San Diego, USA
Drug Discovery Chemistry Booth
April 14
London, UK
RSC BMCS and RSC H&SG symposium: Synthesis in the Agrisciences Sponsoring
April 12 – 13
Berlin, German
Compound Management in Industry and Academia Conference #SLASCM16 Delegate
March 13 – 17
San Diego, USA
251st American Chemical Society National Meeting & Exposition (Computers in Chemistry) Booth,
Presentation

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