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The world's largest collection of building blocks in stock:
225 000 and counting

New Building Blocks

NEWS

May 05, 2020

May 06, 2020

April 2020 Building Block Digest released!

We have reviewed 2 182 compounds synthesized at Enamine past month and would like to share with you some novel structures that we believe will attract your attention.


Read more >>

Accelerating drug discovery

PRESS RELEASE

Apr 15, 2020

April 15, 2020

Enamine and Chemspace collaborate with Blue Dolphin Lead Discovery

Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects. Read more >>

172 723 Fragment compounds
including 27 000 Covalent fragments available from stock

Fragments

PRESS RELEASE

Mar 11, 2020

March 11, 2020

Enamine to be the exclusive supplier of Astex’ MiniFrag Library

Enamine Ltd. and Astex Pharmaceuticals (UK) have cooperated to provide wide access to Astex’ MiniFrag library, an efficient Fragment-based Drug Discovery tool for identification of hot and warm spots of protein targets. The Library is readily available from Enamine in any suitable format, including dry samples or assay-ready high concentration (1M, 100mM) aqueous soaks in containers of preferred type. The detected MiniFrag hits can be followed-up with a wide range of stock available and synthetically feasible derivatives as well as with building blocks for introduction of the relevant structural features for lead optimization. Read more >>

Reach out to new chemical space breaking the availability bias:
14 000 000 000 molecules and beyond

REAL compounds

NEWS

Mar 10, 2020

March 10, 2020

An open-source drug discovery platform enables ultra-large virtual screens

We are delighted to announce another application of Enamine REAL database recently published in Nature. This paper is a result of the collaborative effort of scientists from Enamine and the leading academic institutions from the USA and Germany. Read More >>

Ref.: Nature 2020, in press

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

NEWS

Dec 12, 2019

December 12, 2019

New RNA targeted library has been created!

The number of targets, the number of diseases that one could go after by targeting RNA, is almost unimaginable, says Matt Disney, a chemist at the Scripps Research Institute.

In response to growing interest and recent advancements in targeting RNA our experts designed dedicated library of small molecules predicted to bind to RNA targets. In contrast to the classical protein targets and disease treatment, drugging RNA reveals absolutely new way to treat and prevent different disorders.

Our freshly-made library is ready for fast shipment within a week in various custom formats.

RNA Library contains 8 960 compounds. Read more >>

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from April 2020

Recent News

  • 15 April 2020   Press Releases

    Enamine and Chemspace collaborate with Blue Dolphin Lead ...

    Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects.

    Read press release

  • 30 March 2020   News

    Let’s fight COVID-19 together

    An international group of scientists from academia and industry, including Enamine, is trying to help combat COVID-19. This effort began when Chinese scientists worked rapidly to determine the structure of the novel SARS‑CoV‑2 main protease (Mpro), which triggered a massive crystal-based fragment screen at the XChem facility at UK’s Diamond Light Source. For more details, please visit https://www.diamond.ac.uk/covid-19. With the same urgency, the scientists are now trying to progress these data towards what is desperately needed: effective, easy-to-make anti-COVID drugs https://covid.postera.ai/covid.

  • 11 March 2020   Press Releases

    Enamine to be the exclusive supplier of Astex’ MiniFrag ...

    Enamine Ltd. and Astex Pharmaceuticals (UK) have cooperated to provide wide access to Astex’ MiniFrag library, an efficient Fragment-based Drug Discovery tool for identification of hot and warm spots of protein targets. The Library is readily available from Enamine in any suitable format, including dry samples or assay-ready high concentration (1M, 100mM) aqueous soaks in containers of preferred type. The detected MiniFrag hits can be followed-up with a wide range of stock available and synthetically feasible derivatives as well as with building blocks for introduction of the relevant structural features for lead optimization.

    Read press release

Upcoming events

Enamine takes an active part in the industry’s life participating in the leading international conferences, symposiums, and other events. We will be happy to meet with you, exchange opinions on the latest developments and discuss current projects and future business opportunities. For more information please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it.

2017 year

Date & Venue Event Presence
March 5 – 7
Vienna, Austria
Fragments 2017
6th RSC-BMCS Fragment-based Drug Discovery meeting
TBC

 

2016 year

Date & Venue Event Presence
November 30 – December 1
Lille, France 
Biofit 2016  Delegate 
November 28 – 29
Didcot, UK
Future of Fragments Symposium Sponsoring,
Delegate 
October 25 – 27
Berlin, Germany
12th Global Conference Intelligent Compound Libraries Sponsoring,
Presentation,
Delegate
October 9 – 12
Boston, MA, USA
FBLD 2016
Fragment-based Lead Discovery Conference 2016
TBC
September 28 – 30
Autrans, France
École Thématique de Criblage 2016 Sponsoring
September 11 – 15
Seville, Spain
6th EuCheMS Chemistry Congress Delegate
August 31 –
September 3

Heidelberg, Germany
Chemical Biology 2016 Sponsoring
August 28 –
September 1

Manchester, UK
EFMC-ISMC 2016 Booth #11
August 7 – 12
Kyiv, Ukraine
18th European Symposium on Fluorine Chemistry Organiser
July 12 – 15
Melbourne, Australia 
2nd Fragment Based Drug Discovery Down Under Meeting
(FBDD-DU)
 
Sponsoring 
July 6 – 8
Caen, France
RICT: Interfacing Chemical Biology and Drug Discovery Booth #14
June 26 – 29
Chicago, Il, USA
National Medicinal Chemistry Symposium (NMCS) TBC
June 13 – 15
Verona, Italy
6th RSC / SCI symposium on GPCRs in Medicinal Chemistry TBC
June 2 – 3
Oxford, UK
Drug discovery: creating a new ecosystem Sponsoring 
May 16 – 17
Nottingham, UK
Kinase 2016: Next Generation Inhibitors Sponsoring,
delegate
May 10 – 11
Cambridge, UK
High Content & Phenotypic Screening 2016 (SelectBio) Sponsoring,
delegate
April 21
Hatfield, UK
27th symposium on Medicinal Chemistry in Eastern England Sponsoring
April 19 – 22
San Diego, USA
Drug Discovery Chemistry Booth
April 14
London, UK
RSC BMCS and RSC H&SG symposium: Synthesis in the Agrisciences Sponsoring
April 12 – 13
Berlin, German
Compound Management in Industry and Academia Conference #SLASCM16 Delegate
March 13 – 17
San Diego, USA
251st American Chemical Society National Meeting & Exposition (Computers in Chemistry) Booth,
Presentation

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