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Design and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions

Adv. Synth. Catal. , 2012, 354 (13), 2495-2503

DOI: 10.1002/adsc.201200221

Iaroshenko V. O.; Ostrovskyi D.; Miliutina M.; Maalik A.; Villinger A.; Tolmachev A.; Volochnyuk D. M.; Langer P.

A new strategy for the synthesis of polycyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)-catalyzed intramolecular arylation via CH/C-Hal and CH/CH coupling reactions, was developed. The method proposed here enables the synthesis of many fused N-heterocycles containing purine, 1-deazapurines and benzimidazole structural units.

Design and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions

Iaroshenko V. O.; Ostrovskyi D.; Miliutina M.; Maalik A.; Villinger A.; Tolmachev A.; Volochnyuk D. M.; Langer P.
Adv. Synth. Catal. 2012, 354 (13), 2495-2503
DOI: 10.1002/adsc.201200221

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