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2,2,2-Trifluoroethyl Chlorooxoacetate – Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides

ACS Comb. Sci. 2015, 17 (10), 615-622

DOI: 10.1021/acscombsci.5b00091

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Pipko S. E.; Zhemera A. V.; Konovets A. I.; Stepaniuk O. O.; Myronchuk I. S.; Dmytriv Y. V.; Doroschuk R. A.; Zaporozhets O. A.; Tolmachev A.

A one-pot parallel synthesis of N1-aryl-N2-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.

2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides

 

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