Eur. J. Org. Chem. 2020, 2020 (22), 3261-3269
DOI: 10.1002/ejoc.202000314
Blahun O.; Melnychenko H.; Kuchkovska Y.; Zhersh S.; Tolmachev A.; Grygorenko O.
Two approaches to synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead Nitrogen atom were developed. The target compounds were obtained either by introduction of a CH2SO2 bridge into functionalized monocyclic substrates or by final‐step carboxylation of parent bicyclic cores. The described methods allowed preparation of the final products on a multigram scale.