PyAOP

CAS 156311-83-0, Cat. No EN300-7492597
Reagent for peptide synthesis, C/N/O nucleophiles triphosphorylation

EnamineStore

PyAOP was originally designed as an activator for carboxylic acids but recently found uses in the field of functionalization of intact trimetaphosphate¹. It is a colorless crystals, soluble in CH₂Cl₂, CHCl₃, DMF, DMSO, NMP, THF, CH₃CN, and acetone². As a reagent-activator for carboxylic acids in peptide synthesis, it doesn’t react with primary amines, in contrast to the corresponding uronium/aminium salts which lead to guanidino derivatives. PyAOP is among the most reactive coupling reagents with strong stability, which makes it less effective in automated solid-phase peptide synthesis. The functionalization of trimetaphosphate can be done with primary alcohols, amines, secondary amines, and Wittig reagents to form phosphorus ylide in moderate yield. The reagent can be applied to the triphosphorylation of nucleosides.

Synonyms: (7-azabenzotriazol-1-yloxy)tris (pyrrolidino)phosphonium hexafluorophosphate; tri-pyrrolidinyl[3H-1,2,3-triazolo (4,5-b)pyridin-3-yloxy]phosphonium hexafluorophosphate; tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphonium hexafluorophosphate; PyAOP