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2,2,2-Trifluoroethyl Oxalates in the One-Pot Parallel Synthesis of Hindered Aliphatic Oxamides

Eur. J. Org. Chem. 2016, 12, 2120-2130

DOI: 10.1002/ejoc.201501579

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Pipko S. E.; Grishchenko A. V.; Zhemera A. V.; Konovets A. I.; Doroschuk R. A.; Dmytriv Y. V.; Zaporozhets O. A.; Tolmachev A.

A simple parallel synthesis approach to unsymmetrical N1,N2-substituted aliphatic oxamides using methyl (2,2,2-trifluoroethyl) oxalate and bis(2,2,2-trifluoroethyl) oxalate was developed. The method was validated on a 52-membered set of the oxamides, derived mainly from hindered primary and secondary aliphatic amines, and gave the products with a high overall success rate in moderate yields.

2,2,2-Trifluoroethyl Oxalates in the One-Pot Parallel Synthesis of Hindered Aliphatic Oxamides

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