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Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

Synthesis 2014, 46 (09), 1254-1260

DOI: 10.1055/s-0033-1340840

Yarmoliuk D. V.; Arkhipov V. V.; Stambirskyi M. V.; Dmytriv Y. V.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

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