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Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

Chem. Heterocycl. Compd. , 2014, 50 (4), 514-527

DOI: 10.1007/s10593-014-1502-7

Petrova O. N.; Zamigajlo L. L.; Gella I. M.; Musatov V. I.; Shishkina S. V.; Shishkin O. V.; Vashchenko E. V.; Borisov A. V.; Lipson V. V.

Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4-aroyl-2(1),4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4-aroyl-3-methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.

Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

Petrova O. N.; Zamigajlo L. L.; Gella I. M.; Musatov V. I.; Shishkina S. V.; Shishkin O. V.; Vashchenko E. V.; Borisov A. V.; Lipson V. V.
Chem. Heterocycl. Compd. 2014, 50 (4), 514-527
DOI: 10.1007/s10593-014-1502-7

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