More

  • Home
  • Research
  • Publications
  • The tert-Amino Effect in the Synthesis of Hetaryl- and Arylsulfonyl-Substituted Pyrrolo- and Pyrido[1,2-a]quinoline Derivatives and their Pyrazolo Annulated Analogues

Multigram Synthesis of 1-(Difluoromethyl)imidazoles and -benzimidazoles

Synthesis , 2011, 08, 1243-1248

DOI: 10.1055/s-0030-1258470

Levterov V.; Grygorenko O. O.; Mykhailiuk P. K.; Tolmachev A. A.

An expedient approach to the difluoromethylation of imidazoles and benzimidazoles has been developed. The key feature of the procedure is the gradual generation of the difluoromethylation reagent in the reaction mixture, which is achieved by the simultaneous addition of chlorodifluoromethane and alkali. The method is applicable to functionalized substrates and allows the corresponding 1-(difluoromethyl)imidazoles and -benzimidazoles to be prepared in 60-95% yield on a hundred-gram scale.

Multigram Synthesis of 1-(Difluoromethyl)imidazoles and -benzimidazoles

Levterov V.; Grygorenko O. O.; Mykhailiuk P. K.; Tolmachev A. A.
Synthesis 2011, 08, 1243-1248
DOI: 10.1055/s-0030-1258470

FOLLOW US

Contact us

Send a message