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3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

Org. Lett. , 2010, 12 (19), 4372-4375

DOI: 10.1021/ol101866x

Denisenko A. V.; Mityuk A. P.; Grygorenko O. O.; Volochnyuk D. M.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.

3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

Denisenko A. V.; Mityuk A. P.; Grygorenko O. O.; Volochnyuk D. M.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.
Org. Lett. 2010, 12 (19), 4372-4375
DOI: 10.1021/ol101866x

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