Simple and Convenient Synthesis of 2,3,4,5-Tetrahydro-1,5-dioxopyrrolo[1,2-a]quinazoline- 3a(1H)-carboxylic Acids in Multi-Gram Scale

The title compounds were prepared in 70-100 grams scale by reaction of 2-amino-N-alkyl(aryl)benzamides with 2-oxoglutaric acid. Their structure was proved unambiguously by X-ray crystallographic study.

Tverdokhlebov A. V.; Iminov R. T.; Tolmachev A. A.; Volovenko Y. M.; Kostyuk A. N.; Chernega A. N.; Rusanov E. B.
Heterocycles 2008, 75 (7), 1673-1680
DOI: 10.3987/COM-08-11343