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11 April 2024
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Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024
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March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
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We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
Tetrahedron: Asymmetry
2016, 27 (7-8), 341‑345
DOI:
10.1016/j.tetasy.2016.02.012
Kucher O. V.; Kolodyazhnaya A. O.; Smolii O. B.; Nazarenko N. K.; Kubyshkin V.; Mykhailiuk P. K.; Tolmachev A. A.
The use of lipases offers a simple and straightforward method toward various chiral secondary alcohols. Here we examined the lipase resolution of 1-heteroarylethanols. Racemic substrates were subjected to a two step resolution strategy. The difference between the substituent sizes around the chiral fragment allowed the successful isolation of the (S)-alcohols with assistance of the Burkholderia cepacia lipase (ee ⩾ 96%). The (R)-isomers were obtained after hydrolysis of the enantioenriched O-acetylated alcohols either with Candida antarctica lipase B or with potassium carbonate. The performance of the latter step was found to be substrate dependent.