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Enamine Launches Preclinical Biology Laboratory

Enamine announces opening of contract biology laboratory at its main research site in Kyiv, Ukraine. Enamine’s BioLab will be providing ADMET (absorption, distribution, metabolism, excretion and toxicity) and biomolecular screening services to expand Enamine’s chemistry-driven CRO capabilities into the biological support of early phase drug discovery projects.
Integration of the newly created contract biology lab with Enamine’s internationally renowned synthetic chemistry powerhouse and the vast screening compound repository creates a perfect combination for providing efficient and cost-competitive drug discovery services to the international pharmaceutical and biotech industry.

Change of compound identification in Screening Collection

Enamine is planning to change the numbering of products offered through screening collections in 2012. To facilitate compound tracking in different offerings and allow transparent identification of structures by their unique ID throughout various databases, the old identification method utilizing lot-related T-numbers will be ceased. According to the new identification system all structures referring to compounds offered by Enamine for screening will have unique Z-codes familiar to those who worked with REAL Database before. Existing T-codes will be supported for ordering purposes.

Enamine Launched Peptide Synthesis Laboratory

Solid-Phase Peptide Synthesis was launched by Enamine with a new PS3 Peptide synthesizer (Protein Technologies, Inc.). Small linear and cyclic peptides comprising 2 to 25 amino acid residues of both natural and unnatural origin can be prepared on 1-30 mg scale in a highly pure form (>95%). A large collection of proprietary unnatural amino acids including many conformationally constrained ones as well as ones containing fluorine substituents can be used to expand the variety of peptides. The example structures of peptides prepared with our new peptide synthesizer are listed below.

CF3-Labeled Gramicidin-S analogue Cell-penetrating peptide SAP-E
CF3-Labeled Gramicidin-S analogue
( Angew.Chem., Int. Ed. Engl . 2006 , 45 , 5659-5661)
Cell-penetrating peptide SAP-E
( ChemBioChem 2011, 12 , 896-903)
  CF3-Labeled SAP analogue
CF3-Labeled SAP analogue ( Angew. Chem. Int. Ed. 2008 , 47 , 5765 –5767 )

Enamine hits the stock of building blocks

Over 51,000 low  molecular weight reagents are now available from our stock. To the best of our knowledge, with this amount of substances the company has become the world’s largest supplier of physically available building blocks. The considerable improvement of synthetic technologies at Enamine is pushing the limits of the stock update rate. Currently over 1,000 building blocks are added to the stock every month.

High-throughput synthesis workflow was optimized

Recently Enamine has further improved the high-throughput synthesis workflow used for preparation of compounds offered through the REAL Database. Removal of production bottlenecks, application of optimized technological solutions and expansion of high performance preparative flash chromatography unit allowed us to shorten entire production cycle to 12-14 days. Currently we are able to produce up to 2,000 samples per month using this optimized procedure. 90% feasibility rate can be achieved after a single production cycle for typical compound sets. Compounds synthesized via the enhanced scheme can be delivered within 3 weeks after acceptance of an order.

New version of EnamineStore is launched

EnamineStore at www.enaminestore.com was completely updated – both content and interface were affected by following changes:

  • new products added to catalog: except for stock Screening Compounds and Building Blocks now it is possible to search, browse and order feasible screening compounds (REAL DB) and Tangible Building Blocks
  • new search features: one-click 'Find Analogs' option, advanced search wizard, search by a list of CAS numbers and more
  • tracking and current statuses for orders placed on-line
  • supplemental data on stock compounds updated in catalog
  • new look of catalog and cart pages, color coding for compounds in different categories

Enamine makes analytical data available to the public

As from October 2010 Enamine provides access to NMR and LC/MS data for stock compounds through EnamineStore on-line service. Available spectral data for a compound of interest can be downloaded in PDF format by clicking the "Download spectral data" link located in the "Details" dialog accessible from the catalog section (search results). The analytical data can be accessed by registered users only.

Price reduction on select Enamine Building Blocks

Price of over 9 000 building blocks was reduced by 50% on average. Selected compounds were discounted by as much as 80%! The products affected by price reduction conform to high quality standards of Enamine and are available from stock. Over 1 500 building blocks from this set are also available for rush delivery in 1g batches. You can download the set of discounted building blocks as SDF, ISIS DB or PDF. Please visit EnamineStore to check current stock availability and order on-line.

Screening compounds are offered via three libraries

Starting from January 2010, Enamine starts offering screening compounds via three separate libraries: Advanced, HTS and Historical collection. Advanced collection will always contain only novel and recently synthesized compounds, thus clients who persistently monitor additions to Enamine stock will spend less time and efforts to find new structural motifs. HTS collection will continue to be an indispensable source of compounds for various screening needs, providing unparalleled choice of diverse chemotypes. Historical collection will contain compounds representing scientific heritage of major regional research groups and institutions, particularly interesting for research programs in agro-chemistry and material science.

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