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Essential Fragment Library

Elaborated tool for initial screen

320 compounds

The library was designed in cooperation with research group at University of Cambridge, UK, to be a universal tool for initial screen of novel targets. All compounds in the library have been tested for water solubility and chemical stability in buffer solution to afford a small library of 320 fragments compounds. Our Essential Fragments are especially suitable for the purposes limited by different factors, e.g. validation of new targets, excessive cost of setting up a library for one or two targets, assay particularities etc. In these cases thorough selection of high quality of compounds is extremely important for the successful research.

Key features

  • Increased hit probability – the structures are based on frequently reported fragment hits and scaffolds derived from experimentally determined structures of protein-ligand complexes.
  • Suitable for different screening assays such as fluorescence polarization anisotropy, SPR, ligand-based NMR, thermal shift etc.
  • Experimentally assured solubility at 1 mM, 2mM concentrations in PBS buffer and at 200mM in DMSO solution.
  • Experimentally confirmed chemical stability in aqueous buffer solution (pH 6.5–7.5) at 30 °C for 24 h (by LC-MS method)
  • Compounds with fluorescence interference at 488 or 520 nm and as well as compounds with affinity to CMD-coated surfaces were removed.

Examples of the molecules

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