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Building blocks for DNA-encoded libraries

Library design is an important part of DNA-encoded library (DEL) technology. Enamine has accumulated the world’s largest stock of building blocks, including a substantial number of readily available DEL-compatible reactive compounds. Novelty, exclusivity and favorable physicochemical profiles of Enamine building blocks can largely benefit to the preparation of high-quality DEL’s.

Monofunctional DEL-compatible building blocks

Primary amines Sulfonyl halides Secondary Amines Alkynes
EN300-832810 EN300-817899 EN300-300536 EN300-794488
EN300-832810 EN300-817899 EN300-300536 EN300-794488
> 26 700 in stock
> 60 600 feasible
> 2 900 in stock
> 11 700 feasible
> 15 500 in stock
> 45 300 feasible
> 1 200 in stock
> 8 200 feasible
Carboxylic acids
Boronic acids
Aldehydes
Aryl iodides
EN300-746646 EN300-1266498 EN300-754579 EN300-746793
EN300-746646 EN300-1266498 EN300-754579 EN300-746793
> 22 900 in stock
> 140 000 feasible
> 1 000 in stock
> 1 200 feasible
> 4 200 in stock
> 8 300 feasible
> 1 100 in stock
> 1 100 feasible
Epoxides Alkyl halides Hydrazines Azides
EN300-763017 EN300-1301378 EN300-729685 EN300-719606
EN300-763017 EN300-1301378 EN300-729685 EN300-719606
> 450 in stock
> 2 200 feasible
> 7 200 in stock
> 17 400 feasible
> 900 in stock
> 950 feasible
> 700 in stock
> 1 800 feasible

Bifunctional DEL-compatible scaffolds

14 000 small and rigid scaffolds bearing commonly employed combinations of orthogonal functional groups available in stock or offered for synthesis.

Acid – Aryl halide Aldehyde – Aryl halide Fmoc-Amino acids
EN300-264167 EN300-233158 EN300-89327
EN300-264167 EN300-233158 EN300-89327
2 225 in stock
+3 900 feasible
547 in stock
+1 490 feasible
> 500 in stock
> 2000 feasible

Other classes include:

 

Hundreds of compounds from stock can be delivered within 1-2 weeks, while larger lists of several thousand building blocks will require 3 weeks. We supply in µmol amounts in containers of your choice.

Trifunctional DEL-compatible scaffolds

13 500 small and rigid scaffolds bearing commonly employed combinations of orthogonal functional groups available in stock or offered for synthesis.

Acid - Boc-Amine - Fmoc-Amine Acid - Aryl halide - Nitro Acid - Aldehyde - Aryl halide
EN300-183615 EN300-124838 EN300-318194
EN300-183615 EN300-124838 EN300-318194
9 in stock
+6 190 feasible
37 in stock
+5 090 feasible
7 in stock
+800 feasible
     
Acid - Ester - Boc-Amine Acid - Alkyne - Boc-Amine
EN300-87440 EN300-172817
EN300-87440 EN300-172817
4 in stock
+290 feasible
5 in stock
+100 feasible

Other classes include:

We continuously expand our portfolio of scaffolds and will be happy to use our expertise in custom synthesis of building blocks designed by you.



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