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Premium Collection

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Enamine Premium Collection contains over 137 597 compounds having most favorable molecular properties (high Fsp3, low logP and MW). They have been synthesized in our lead-oriented synthesis program. Remarkable success achieved by Enamine in synthesizing novel lead-like compound libraries is explained by usage of robust and sustainable chemical methodology which concept is based on development of the building block inventory. While designing new molecular scaffolds we not only address the issue of molecular properties and pharmacophore composition of the derived compounds but also the cost factor related to follow-up of the found hits. Owing to the high degree of chemistry validation and availability of the analogous building blocks from our catalogue the hit-to-lead process runs fast and smoothly.

MW 347.4
ClogP 1.19

Z1136426268, racemic
MW 349.4
ClogP 2.02

MW 343.4
ClogP 0.91

Figure 1. Examples of compounds from Premium collection.

Figure 2. Distribution of the compounds from Premium Collection by selected molecular parameters.

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