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Amino nitriles
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Bifunctional building blocks are of special interest for drug design and organic synthesis due to three reasons, at least. First, these compounds can be used to tether two molecular fragments responsible for binding to the biological target, thus they can act as linkers. Second, if one functional group is not engaged in connection between the core of building block and the rest of a molecule being constructed, then it can participate in important interaction with a biological target. Finally, many bifunctional building blocks can undergo cyclization reactions, allowing rapid advance toward prospective heterocyclic units.

Amino Nitriles are especially potent representatives of bifunctional compounds. Importance of Amino moiety for drug design is hard to overestimate due to a set of intrinsic properties, i. e. ability to act as hydrogen bond donor and acceptor or to be involved into electrostatic interactions (after protonation), diversity of chemical modification pathways (acylation, alkylation, reductive alkylation reactions), predictable chemical reactivity and reliability of chemical transformations allowing their use in combinatorial synthesis. On the other hand, Nitrile functional group can be involved into hydrogen-bonding or π-π interactions, furthermore, it can be selectively transformed to primary amine or aldehyde (reduction), ketone (organometallic addition) or carboxylic acid (hydrolysis). The latter transformation is involved in a classical α-amino acid synthesis, namely, Strecker synthesis.

Schematic representation of amino nitrile features
Features of common amino nitriles.

Enamino Nitriles form a special subclass of Amino Nitriles and deserve a separate description. If amino- and nitrile- groups are connected via a double bond (which often is a part of a five-membered cycle), chemical properties of both functional groups are changed drastically because of strong mesomeric interaction. Basic and nucleophilic properties of amino group are almost abolished, whereas electrophilicity of nitrile is enhanced. These peculiarities make enamino nitriles attractive intermediates in synthesis of various heterocyclic derivatives.

Schematic representation of enamino nitriles
Enamino nitriles and their derivatives.

Enamine offers two subsets of Amino Nitrile building blocks. Aliphatic and the most aromatic amino nitriles are aimed to be used as classical orthogonally bifunctional building blocks, whereas enamino nitriles and their heterocyclic analogues were designed for the synthesis of heterocycles. Procedures developed for the synthesis of Amino Nitriles allow production of highly diverse sets of these building blocks on 1–10 g scale; we can also synthesize novel compounds based on a requested structure within 4–8 weeks. Scale-up to 1 kg can be performed upon request. Moreover, we have broad in-house experience of further in-house modification of Amino Nitriles, in particular, using heterocyclization reactions. Some examples of Amino Nitriles are shown below. Please download the complete Enamine Amino Nitriles set for your convenience.

Aliphatic Amino Nitriles

EN300-31050 EN300-08537 EN300-08665
EN300-29407 EN300-10281 EN300-10077
EN300-06776 EN300-06631 EN300-31941
EN300-33441 EN300-31293 EN300-33430
EN300-33756 EN300-23157 EN300-31047

Aromatic Amino Nitriles

EN300-24524 EN300-39906 EN300-10992
EN300-33158 EN300-32046 EN300-36988

Enamino Nitriles and their heterocyclic analogues

EN300-26208 EN300-02285 EN300-02283
EN300-36977 EN300-13803 EN300-09764

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