N-(tert-Butoxycarbonyl)sulfamoyl chloride is a highly versatile and reactive electrophilic sulfamoylating reagent that has found extensive use in organic synthesis. This compound is a white powder that is soluble in a wide range of solvents and performs well in soft reaction conditions. It readily reacts with nucleophiles, allowing for the formation of a variety of sulfamates, sulfamides, hydroxysulfamides, and sulfonamides through reactions with alcohols, amine, hydroxylamines, and carbon-based nucleophiles. One of the important advantages of reagent comperes to sulfamoyl chloride is that the product has a Boc protective group after the reaction. It can minimize the number of stages in synthesis and facilitate the purification process of the product.
Synonyms: N-(tert-Butoxycarbonyl)sulfamoyl Chloride, tert-butyl N-(chlorosulfonyl)carbamate, Tert-butyl chlorosulfonylcarbamate, N-Boc-sulfamoyl chlorid