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Saturated Bioisosteres of Benzene with Improved Solubility

“Escape the Flatland” concept has already gained considerable attention in medicinal chemistry. Scientists are looking more and more now for 3D-shaped saturated building blocks. In this context, conformationally rigid bicyclic tetrahydrofurans are intrinsically promising for drug discovery. In continuation of our ongoing program towards novel building blocks for drug discovery, herein we have designed and synthesized a library of saturated mimics of the benzene ring with improved solubility in water.

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We offer more than 100 mono- and disubstituted benzene mimics with improved water solubility from stock on a 5-10 g scale:

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