Mykhailiuk, P. K. Generation of C2F5CHN2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes Chem. Eur. J. 2014, 17, 5168. (Back Cover Picture)
Ritter, S. K. Diazoalkane Expands Fluorine Focus On Ethyl Groups Chemical & Engineering News, 92 (17), 2014.
Developing new methods for introducing fluorine into complex organic molecules has been all the rage during the past few years. Researchers preparing drug candidates and crop-protection chemicals typically seek to add a single fluorine atom or trifluoromethyl group and now have myriad ways to do so. But methods for adding longer, more lipophilic perfluoroalkyl groups, such as pentafluoroethyl, –C2F5, to complex molecules are relatively scarce. The approaches tend to be direct additions of C2F5 using organometallic transfer reagents and don’t utilize C2F5-containing building blocks.
Enamine scientists have developed a new building block for introducing C2F5 group into organic molecules. Pavel Mykhailiuk and colleagues safely generated the fluorinated diazoalkane, C2F5CHN2, in situ from C2F5CH2NH2•HCl and NaNO2. Authors demonstrated the utility of the reagent by using it in [3 + 2]-cycloadditions with mono- and disubstituted alkenes at room temperature to prepare perfluoroethylated pyrazolines with better than 95% conversion rates. Authors believe the diazofluoroalkane will also be as useful as other diazoalkanes for cyclopropanations, carbene insertions, and alkyne cycloadditions.
Building Blocks Catalog
300 Thousand compounds in stock
Original and unique
Make-on-demand
Building Blocks
1B novel building blocks
Reliable supply
Custom Synthesis
Over 650 highly skillful chemists
Unique synthesis technologies
Library Synthesis
48B Billion REAL compounds and
Custom Library Synthesis
FTE Chemistry Support
On site access to all Enamine stock BB’s
Highly flexible arrangements
2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2024
Recent News
11 April 2024 Press Release
Metrion Biosciences enhances High Throughput Screening services with access ...
Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024 Press Release
Enamine Announces Expansion of Its Library Synthesis Capabilities
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024 News
Enamine and Genez International Announce Strategic Collaboration to Launch ...
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.