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120 000 Fragment compounds
including 10 000 covalent binders

Fragments

NEWS

June 25, 2019

June 25, 2019

Enamine’s covalent fragments
produce potent and unique hits

In a recent JACS paper several academic groups collaborated on discovery of novel covalent inhibitors using a library of 993 acrylamides and chloroacetamides sourced from Enamine’s covalent fragment collection. The design was focusing on mild electrophiles that were supposed to overcome the selectivity challenge. The library was characterized by a new high-throughput thiol-reactivity assay and screened against 10 cysteine-containing proteins. Potent and unique primary hits have been found in the majority (7 out of 10) of cases.

A refined library used in the research with a few frequent hitters and excessively reactive fragments removed is available from Enamine on request >

Ref.: J. Am. Chem. Soc. 2019, 141, 8951−8968

Reach out to new chemical space breaking the availability bias:
11 000 000 000 molecules and beyond

REAL compounds

NEWS

June 24, 2019

June 24, 2019

Atomwise and Enamine to Advance Pediatric Oncology With the World’s First and Largest Ten Billion Compound Virtual Screen

10 Billion REAL compounds will be searched using AI powered drug screening platform to find novel small molecules for the treatment of pediatric cancers. In collaboration with academic researchers, Atomwise and Enamine said the “10-to-the-10 program” will seek to maximize the opportunity to develop drugs for new target proteins to inhibit cancer growth and metastasis. Read PRESS RELEASE >

The world’s largest collection of building blocks in stock:
172 456 and counting

New Building Blocks

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

A broad test panel to support lead discovery
Integrated projects or a-la-carte service

ADME/T & in-vivo PK

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from June 2019

Recent News

  • 25 June 2019   News

    Enamine’s covalent fragments produce potent and unique hits

    In a recent JACS paper several academic groups collaborated on discovery of novel covalent inhibitors using a library of 993 acrylamides and chloroacetamides sourced from Enamine’s covalent fragment collection. The design was focusing on mild electrophiles that were supposed to overcome the selectivity challenge. The library was characterized by a new high-throughput thiol-reactivity assay and screened against 10 cysteine-containing proteins. Potent and unique primary hits have been found in the majority (7 out of 10) of cases.

  • 24 June 2019   Press Releases

    Atomwise and Enamine to Advance Pediatric Oncology With the ...

    Atomwise, Enamine, and top university researchers collaborate to discovery novel small molecules for the treatment of pediatric cancers using the power of AI and novel chemistry.

    Read press release

  • 26 March 2019   Press Releases

    Enamine extends multi-year drug discovery collaboration with Lundbeck

    Enamine and H. Lundbeck A/S (Lundbeck) announced the expansion of their research collaboration. Enamine will support Lundbeck’s in-house discovery chemistry competencies with three principal assets enabling Lundbeck to optimally identify and develop hit series in its multiple research programs. A large diverse library of 100 000 new screening compounds was done for hit finding activities on numerous therapeutic targets. Enamine’s make-on-demand REAL compounds are for efficient access to billions of novel chemical compounds. Enamine FTE increased dedicated team of chemists to effectively support Lundbeck on all hit related follow-up activities backed by immediate access to over 170 000 building blocks in Enamine’s inventory.

    Read press release

Upcoming events

Having more than 913 155 building blocks, intermediates and scaffolds in stock (typically in 5-30 g amounts), Enamine is in a position to offer the most comprehensive scope of compound library design and synthesis services on the market.

Key Facts:

  • A library of up to 300 compounds is normally shipped within 3 weeks (up to 20 mg)
  • 60 Reactions (acylation, reductive amination, sulfonylation, aromatic nucleophilic substitution, etc.) are optimized for parallel synthesis including metal-catalyzed reactions in inert atmosphere
  • RP HPLC purification is the immutable standard at Enamine

Our Business Models in Library Synthesis

Model 1.Collaborations using templates and scaffolds

  • 100% Collaborative approach
  • You decide on type of decorative chemistry, number of variations (matrix), and select the end-compounds to synthesize
  • Validated chemistry. Libraries can be built even on in stock scaffolds that have just been synthesized
  • Optional exclusivity

Model 2.Decoration of your scaffolds

You can send us your scaffold compounds for decoration with our building blocks

  • 100 compounds – 2-3 weeks only!
  • Flat price per compound

Model 3.Collaborations using Express Lead Library approach

A significant number of novel building blocks synthesized by Enamine possess essential complexity and dense pharmacophore architecture, e.g.:

  • Convenient selection of molecular cores
  • Any number of derived compounds per core building block
  • Fast and confident delivery (80% success rate)

Model 4.Sourcing compounds from REAL compound arrays

Enamine offers an unprecedentedly large chemical space of over 230 M synthetically accessible compounds - REAL Arrays. The compounds are searchable at EnamineStore.com (similarity search), or can be provided in a database format clustered into subgroups:

  • Fragments
  • Lead-like compounds
  • Sp 3-Rich compounds
  • Carboxylic acids
  • Secondary amines
  • Covalent modifiers
  • PPI modulators
  • Annotated – analogues of the known bioactive compounds
  • 2016 update – built with building blocks synthesized in 2016

and any subset based on your selection criteria

Once you select desired compounds to be included in the library, we perform its synthesis. We guarantee the following terms of our services:

  • Short synthesis time: 3 weeks for up to a few hundred compounds
  • High success rate: 80-90% for small libraries (up to 150 compounds)
  • Simple compound purchase orders

Other services which might be useful to you: