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Reach out to new chemical space breaking the availability bias:
11 000 000 000 molecules and beyond

REAL compounds

The world’s largest collection of building blocks in stock:
169 144 and counting

New Building Blocks

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

120 000 Fragment compounds
including 10 000 covalent binders

Fragments

A broad test panel to support lead discovery
Integrated projects or a-la-carte service

ADME/T & in-vivo PK

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from May 2019

Recent News

  • 26 March 2019   Press Releases

    Enamine extends multi-year drug discovery collaboration with Lundbeck

    Enamine and H. Lundbeck A/S (Lundbeck) announced the expansion of their research collaboration. Enamine will support Lundbeck’s in-house discovery chemistry competencies with three principal assets enabling Lundbeck to optimally identify and develop hit series in its multiple research programs. A large diverse library of 100 000 new screening compounds was done for hit finding activities on numerous therapeutic targets. Enamine’s make-on-demand REAL compounds are for efficient access to billions of novel chemical compounds. Enamine FTE increased dedicated team of chemists to effectively support Lundbeck on all hit related follow-up activities backed by immediate access to over 170 000 building blocks in Enamine’s inventory.

    Read press release

  • 12 February 2019   News

    Enamine to Support Large-scale Hit Discovery Programs via New ...

    Scientists at the UCSF, together with colleagues at the UNC, created the largest “docking-friendly” database of molecules, based on the Readily Accessible (REAL) compounds from Enamine. Practical validation of the new database was recently published in Nature magazine, demonstrating that it is capable of identifying extremely powerful and synthetically available new hits.

  • 05 February 2019   News

    Horizon 2020 Project PELICO, Coordinated by Enamine, Achieves Promising ...

    EU-funded project PELICO, under Enamine’s coordination, reports promising results in synthesis of peptides, their pharmacokinetic and toxicity studies, and coupling with photo-controlled building blocks to yield new photo-controlled peptidomimetics.

Upcoming events

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

Re-supply and re-synthesis of hit compounds.

We will help you to assess quality of your hit compounds by pointing out at possible promiscuous structures, frequent hitters, and by revising their analytics in our archive. In most cases we can deliver additional amounts of the hit compounds directly from our stock.

Otherwise we can re-synthesize them fairly quickly taking advantage of the chemical procedures and building blocks available in-house.

All compounds from our screening collection were designed and synthesized in our laboratories. This means that we possess both knowledge and starting materials to prepare larger batches of the selected compounds within the shortest possible timeframe.

Re-synthesis samples will be delivered with certificates of analysis including NMR and LCMS data reports. Upon project finalization we can provide you with detailed chemical procedures to use them in your publications or patent applications.

Compound libraries supplies for hit explosion, lead generation and optimization.

We will be happy to work with you and assist you, as you would need, in design of focused libraries in any phase of your project and provide you with adequate medicinal chemistry support.

Usually synthesis of close analogues takes only a few weeks, if not already available on our stock. The compounds, especially in the early lead discovery phase, are delivered on a fixed-price basis implying zero risks on your side: you only pay for the compounds that are delivered according to your exact specifications and the final report provided.

In the advanced collaboration phase with dynamically changing synthesis plans it becomes more appropriate to establish an FTE service agreement for several months. Exact duration depends on the nature of the project. Enamine offers most attractive FTE rate in Eastern Europe which, in addition, includes access to the world’s largest inventory of building blocks used in medicinal chemistry.

Services for lead generation and optimization can be further supported with CADD and ADMET-DMPK studies of the synthesized compounds directly at Enamine.

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