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Building Block Catalogue

225 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

14 Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2021

Recent News

  • 05 April 2021   News

    Open positions for Postdocs and Research Scientists

    We still have several funded Postdoc positions in organic chemistry to work at Enamine Ltd. (Ukraine, Kyiv) on a ERC-project “Saturated bioisosteres of benzene.”

    Start: any time.
    Please, send the application documents (motivation letter, CV, list of publications, recommendation letters) to Pavel.MykhailiukATmail.enamine.net

  • 01 March 2021   News

    Lumobiotics GmbH is part of an European consortial Project

    We are happy to announce the start of Project ALISE supported by European Commission under Horizon 2020 MSCA-RISE. As the coordinator of the Project, Enamine is involved in the development of light-controllable antibody peptide conjugates pushing the boundaries of photopharmacology towards clinical applications.

  • 24 February 2021   Press Releases

    Enamine extend collaboration with prominent Swiss Biotech

    A new multi-year drug discovery agreement will focus on CNS drug discovery

    Kyiv, Ukraine, February 24 2021 - Enamine Ltd. a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments and screening compounds announced today that it has extended its long-standing research collaboration with Addex Therapeutics Ltd (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company specialized in allosteric modulation-based drug discovery and development. Enamine is providing Addex with its integrated capability in medicinal chemistry, pharmacology and ADME/PK (Absorption, Distribution, Metabolism, Excretion/Pharmacokinetics) to efficiently support Addex’ small molecule CNS drug discovery programs.

    Read press release

Upcoming events

Ro3 Fragment Library

General set of Ro3 compliant molecules for cherry-picking

[Ro3-F][/Ro3-F] compounds

Enamine’s design and synthesis capabilities allow the addition of more than 140 000 new organic compounds to its catalogue each year. Fast growth and permanent enhancement of our Building Block Collection with novel, top level synthetic chemistry molecules resulted in the world largest set of high quality fragments.

Enamine Ro3 Fragments comprise a remarkable number of new scaffolds and unique chemotypes within the widest range of molecular frameworks. The library does not include covalent modifiers and toxicophores, all industry affiliated exclusion filters and MedChem refinements have been applied.

Key features

  • [Ro3-F][/Ro3-F] molecules out of 2 790 127 Collection
  • Ro3 compliance – 100%, Heavy atoms 9…19
  • MedChem inspection & Chemotype control
  • Sensible Diversity – 32% mean Tanimoto distance (ECFP4)

Key benefits

The hits discovered from our fragments are expected to yield lead compounds fast and easily. Follow-up investigation can be readily performed with analogues available from stock, REAL database in one stage conversion or derived from new MedChem-driven synthesis. All required intermediates, core building blocks and decorating reagents are available from Enamine stock Collection.

Examples of the molecules in the library

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