Ro3 Fragment Library
General set of Ro3 compliant molecules for cherry-picking
Enamine’s design and synthesis capabilities allow the addition of more than 140 000 new organic compounds to its catalogue each year. Fast growth and permanent enhancement of our Building Block Collection with novel, top level synthetic chemistry molecules resulted in the world largest set of high quality fragments.
Enamine Ro3 Fragments comprise a remarkable number of new scaffolds and unique chemotypes within the widest range of molecular frameworks. The library does not include covalent modifiers and toxicophores, all industry affiliated exclusion filters and MedChem refinements have been applied.
- [Ro3-F][/Ro3-F] molecules out of 2 790 127 Collection
- Ro3 compliance – 100%, Heavy atoms 9…19
- MedChem inspection & Chemotype control
- Sensible Diversity – 32% mean Tanimoto distance (ECFP4)
The hits discovered from our fragments are expected to yield lead compounds fast and easily. Follow-up investigation can be readily performed with analogues available from stock, REAL database in one stage conversion or derived from new MedChem-driven synthesis. All required intermediates, core building blocks and decorating reagents are available from Enamine stock Collection.