225 Thousand compounds in stock
Original and unique
210 Million novel building blocks
Over 650 highly skillful chemists
Unique synthesis technologies
14 Billion REAL compounds and
Custom Library Synthesis
On site access to all Enamine stock BB’s
Highly flexible arrangements
2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from July 2020
15 April 2020
Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects.
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30 March 2020
An international group of scientists from academia and industry, including Enamine, is trying to help combat COVID-19. This effort began when Chinese scientists worked rapidly to determine the structure of the novel SARS‑CoV‑2 main protease (Mpro), which triggered a massive crystal-based fragment screen at the XChem facility at UK’s Diamond Light Source. For more details, please visit https://www.diamond.ac.uk/covid-19. With the same urgency, the scientists are now trying to progress these data towards what is desperately needed: effective, easy-to-make anti-COVID drugs https://covid.postera.ai/covid.
11 March 2020
Enamine Ltd. and Astex Pharmaceuticals (UK) have cooperated to provide wide access to Astex’ MiniFrag library, an efficient Fragment-based Drug Discovery tool for identification of hot and warm spots of protein targets. The Library is readily available from Enamine in any suitable format, including dry samples or assay-ready high concentration (1M, 100mM) aqueous soaks in containers of preferred type. The detected MiniFrag hits can be followed-up with a wide range of stock available and synthetically feasible derivatives as well as with building blocks for introduction of the relevant structural features for lead optimization.
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We offer our unique compound libraries intended to reach a wide range of drug discovery purposes and agro/crop science projects. The recent scientific data and versatile advanced technologies in computational chemistry were applied to design our focused sets. The main features of our approach to library design based on medicinal chemistry inspection combined with high novelty and reasonable priced molecules with validated synthetic methods.
Our sets of high-quality small molecules aimed to meet the most sophisticated drug discovery projects with capabilities of the extremely fast hit-follow-up programs.
493 968 compounds
Collection of Fragments and Lead-like molecules
2 115 979 compounds
The largest source of good-quality chemicals for HTS screening
44 685 compounds
Subset of Novel and highly valuable molecules
680 million compounds
The largest enumerated database of synthetically feasible molecules
172 723 compounds
The largest Collection of in-stock Fragments
2 100 compounds
Collection of referred small molecules with carefully collected activity data
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.