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The world's largest collection of building blocks in stock:
225 000 and counting

New Building Blocks

NEWS

May 05, 2020

May 06, 2020

April 2020 Building Block Digest released!

We have reviewed 2 182 compounds synthesized at Enamine past month and would like to share with you some novel structures that we believe will attract your attention.


Read more >>

Accelerating drug discovery

PRESS RELEASE

Apr 15, 2020

April 15, 2020

Enamine and Chemspace collaborate with Blue Dolphin Lead Discovery

Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects. Read more >>

172 723 Fragment compounds
including 27 000 Covalent fragments available from stock

Fragments

PRESS RELEASE

Mar 11, 2020

March 11, 2020

Enamine to be the exclusive supplier of Astex’ MiniFrag Library

Enamine Ltd. and Astex Pharmaceuticals (UK) have cooperated to provide wide access to Astex’ MiniFrag library, an efficient Fragment-based Drug Discovery tool for identification of hot and warm spots of protein targets. The Library is readily available from Enamine in any suitable format, including dry samples or assay-ready high concentration (1M, 100mM) aqueous soaks in containers of preferred type. The detected MiniFrag hits can be followed-up with a wide range of stock available and synthetically feasible derivatives as well as with building blocks for introduction of the relevant structural features for lead optimization. Read more >>

Reach out to new chemical space breaking the availability bias:
14 000 000 000 molecules and beyond

REAL compounds

NEWS

Mar 10, 2020

March 10, 2020

An open-source drug discovery platform enables ultra-large virtual screens

We are delighted to announce another application of Enamine REAL database recently published in Nature. This paper is a result of the collaborative effort of scientists from Enamine and the leading academic institutions from the USA and Germany. Read More >>

Ref.: Nature 2020, in press

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

NEWS

Dec 12, 2019

December 12, 2019

New RNA targeted library has been created!

The number of targets, the number of diseases that one could go after by targeting RNA, is almost unimaginable, says Matt Disney, a chemist at the Scripps Research Institute.

In response to growing interest and recent advancements in targeting RNA our experts designed dedicated library of small molecules predicted to bind to RNA targets. In contrast to the classical protein targets and disease treatment, drugging RNA reveals absolutely new way to treat and prevent different disorders.

Our freshly-made library is ready for fast shipment within a week in various custom formats.

RNA Library contains 8 960 compounds. Read more >>

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from April 2020

Recent News

  • 15 April 2020   Press Releases

    Enamine and Chemspace collaborate with Blue Dolphin Lead ...

    Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects.

    Read press release

  • 30 March 2020   News

    Let’s fight COVID-19 together

    An international group of scientists from academia and industry, including Enamine, is trying to help combat COVID-19. This effort began when Chinese scientists worked rapidly to determine the structure of the novel SARS‑CoV‑2 main protease (Mpro), which triggered a massive crystal-based fragment screen at the XChem facility at UK’s Diamond Light Source. For more details, please visit https://www.diamond.ac.uk/covid-19. With the same urgency, the scientists are now trying to progress these data towards what is desperately needed: effective, easy-to-make anti-COVID drugs https://covid.postera.ai/covid.

  • 11 March 2020   Press Releases

    Enamine to be the exclusive supplier of Astex’ MiniFrag ...

    Enamine Ltd. and Astex Pharmaceuticals (UK) have cooperated to provide wide access to Astex’ MiniFrag library, an efficient Fragment-based Drug Discovery tool for identification of hot and warm spots of protein targets. The Library is readily available from Enamine in any suitable format, including dry samples or assay-ready high concentration (1M, 100mM) aqueous soaks in containers of preferred type. The detected MiniFrag hits can be followed-up with a wide range of stock available and synthetically feasible derivatives as well as with building blocks for introduction of the relevant structural features for lead optimization.

    Read press release

Upcoming events

Compound collections

We offer our unique compound libraries intended to reach a wide range of drug discovery purposes and agro/crop science projects. The recent scientific data and versatile advanced technologies in computational chemistry were applied to design our focused sets. The main features of our approach to library design based on medicinal chemistry inspection combined with high novelty and reasonable priced molecules with validated synthetic methods.

Our sets of high-quality small molecules aimed to meet the most sophisticated drug discovery projects with capabilities of the extremely fast hit-follow-up programs.

Product catalog

Product name
Format/Size
Descriptions
Download file

Format/Size

482 182 compounds

Descriptions

Collection of Fragments and Lead-like molecules

Download file

&nsbp;

Format/Size

2 121 382 compounds

Descriptions

The largest source of good-quality chemicals for HTS screening

Download file

&nsbp;

Format/Size

43 525 compounds

Descriptions

Subset of Novel and highly valuable molecules

Download file

&nsbp;

Format/Size

680 million compounds

Descriptions

The largest enumerated database of synthetically feasible molecules

Download file

Format/Size

172 723 compounds

Descriptions

The largest Collection of in-stock Fragments

Download file

Format/Size

2 100 compounds

Descriptions

Collection of referred small molecules with carefully collected activity data

Download file

&nsbp;

Support

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

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