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Building Block Catalogue

225 Thousand compounds in stock

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Building Blocks

210 Million novel building blocks

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Library Synthesis

14 Billion REAL compounds and

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from September 2020

Recent News

  • 24 September 2020   Press Releases

    Enamine is selected for Horizon 2020 global project “AIDD” ...

    Enamine Ltd., a leading chemical research organization and producer of the world’s largest collections of novel building blocks (225,000+) and screening compound libraries (2,740,000+), has joined the Advanced Machine Learning for Innovative Drug Discovery (AIDD) program, funded by the European Union within the framework of the Marie-Skłodowska-Curie Actions (MSCA) with a budget of Euros 3.93 million. The project, coordinated by Helmholtz Zentrum München,Germany, brings together fifteen institutions from eleven countries in addition to the University of British Columbia (Canada) to train sixteen PhD students in close collaboration with associated partners from the USA, Australia, China, Israel and other countries and develop next generation AI and Machine Learning (ML) models and systems for drug discovery.

    Read press release
  • 17 September 2020   Press Releases

    Enamine Ltd. Released Coronavirus Library to Support COVID-19 Research ...

    Enamine Ltd., a leading chemical research organization and producer of the world’s largest collections of novel building blocks (225,000+) and screening compound libraries (2,740,000+), today announced the release of the Coronavirus Library. The new screening library capitalizes on Enamine’s decades of chemical R&D, advanced library design expertise, and experience with creating focused antiviral libraries. Enamine is a participant of a global Open Science initiative “COVID Moonshot”, aimed at discovering novel therapeutics against SARS-CoV-2.

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  • 15 April 2020   Press Releases

    Enamine and Chemspace collaborate with Blue Dolphin Lead ...

    Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects.

    Read press release

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Bcl9/PYGO/Histone 3 Interaction Inhibitors library

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317 compounds

As yet another option to block Wnt/Fz signaling, we turned our attention to PYGO/Histone 3 interaction (Figure 1A). Notably, it has been shown earlier that small molecules could bind PHD domain of PYGO that engages methylated Histone 3 residue. This results in disrupted interaction of β-catenin and Bcl9.

Fig. 1.(a) Interaction interface of BCL9/PYGO/Histone 3; (b) Representative molecule bound to the key amino acids of H3K4me2.

Docking and scoring studies of the resultant hits yielded a selection of 317 small molecules. A representative ligand mediating multiple hydrophilic interactions, π-stacking with Phe366 and hydrogen bonds is shown on Figure 1B.

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