225 Thousand compounds in stock
Original and unique
Make-on-demand
Building Blocks
210 Million novel building blocks
Reliable supply
Over 650 highly skillful chemists
Unique synthesis technologies
14 Billion REAL compounds and
Custom Library Synthesis
On site access to all Enamine stock BB’s
Highly flexible arrangements
2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from September 2020
Recent News
24 September 2020
Press Releases
Enamine Ltd., a leading chemical research organization and producer of the world’s largest collections of novel building blocks (225,000+) and screening compound libraries (2,740,000+), has joined the Advanced Machine Learning for Innovative Drug Discovery (AIDD) program, funded by the European Union within the framework of the Marie-Skłodowska-Curie Actions (MSCA) with a budget of Euros 3.93 million. The project, coordinated by Helmholtz Zentrum München,Germany, brings together fifteen institutions from eleven countries in addition to the University of British Columbia (Canada) to train sixteen PhD students in close collaboration with associated partners from the USA, Australia, China, Israel and other countries and develop next generation AI and Machine Learning (ML) models and systems for drug discovery.
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17 September 2020
Press Releases
Enamine Ltd., a leading chemical research organization and producer of the world’s largest collections of novel building blocks (225,000+) and screening compound libraries (2,740,000+), today announced the release of the Coronavirus Library. The new screening library capitalizes on Enamine’s decades of chemical R&D, advanced library design expertise, and experience with creating focused antiviral libraries. Enamine is a participant of a global Open Science initiative “COVID Moonshot”, aimed at discovering novel therapeutics against
SARS-CoV-2.
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15 April 2020
Press Releases
Today Enamine, a leading provider of small molecules and drug discovery services, Chemspace, an online catalog with the largest offer of small molecules to search and buy, and Blue Dolphin Lead Discovery, a research organization focused on a fee-for-service virtual screening, announced the launch of the collaboration to support drug discovery projects.
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Express Lead Library
Readily accessible lead-like libraries based on Enamine's latest core building blocks with unique underrepresented structures
5.82 M compounds
Express Lead Library (ELL) is an extension of REAL database focusing on novel screening compounds that can be synthesized from the most recently synthesized building blocks. Having the largest building block inventory Enamine continues its expansion. Each month it is enriched with 2,000 new functionalized compounds synthesized in-house. Many of them feature results of our latest research in medchem-driven organic synthesis. Following our doctrine of accelerating drug discovery it’s important to make such chemotypes available for biological screening as soon as possible. We have selected only unusual building blocks that contain at least 2 rings or 7-membered rings. They are called “core building blocks” as they bear essential molecular complexity rendering novelty to the enumerated compound libraries. All terms of REAL database including synthesis time of 3 weeks with at least 85% success rate are also valid for supplies from ELL. It is recommended as an abundant source of selected novel compounds in Compound Collection Enhancement programs and virtual screening projects.
- 1 592 New building blocks synthesized in 2015-2017
- Exclusivity. Over 90 % are offered on the market only by Enamine
- Unique underrepresented structures. The selected building blocks have no close analogues in stock and have not been largely used for library synthesis: > 92 % have less than 25 derivatives in our stock screening collection
- Essential molecular complexity. Fragment complexity > 600
ELL molecules
- 5.82 Million new compounds
- Lead-like physicochemical profiles: MW < 350, sLogP < 3.5 or MW < 400, sLogP < 3, rotatable bonds < 6 (no long chains, < 4 open-chain atoms), aromatic rings < 3 (at least one heteroaromatic)
- Balanced diversity, no singletons: 107 572 Murcko frameworks, > 5 molecules/framework, 92 % has < 100 molecules/framework
- No toxic or unwanted groups. Filters applied: PAINS, NO2, CN, ester, triflate, sulfoxide, open-chain sulfide, terminal alkyne, carbamate, Boc-, Fmoc-, aryl/alkyl bromide/iodide, aldehyde, 2-halo pyridine/pyrimidine, oxamides
