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Building Block Catalogue

225 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

14 Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2021

Recent News

  • 05 April 2021   News

    Open positions for Postdocs and Research Scientists

    We still have several funded Postdoc positions in organic chemistry to work at Enamine Ltd. (Ukraine, Kyiv) on a ERC-project “Saturated bioisosteres of benzene.”

    Start: any time.
    Please, send the application documents (motivation letter, CV, list of publications, recommendation letters) to Pavel.MykhailiukATmail.enamine.net

  • 01 March 2021   News

    Lumobiotics GmbH is part of an European consortial Project

    We are happy to announce the start of Project ALISE supported by European Commission under Horizon 2020 MSCA-RISE. As the coordinator of the Project, Enamine is involved in the development of light-controllable antibody peptide conjugates pushing the boundaries of photopharmacology towards clinical applications.

  • 24 February 2021   Press Releases

    Enamine extend collaboration with prominent Swiss Biotech

    A new multi-year drug discovery agreement will focus on CNS drug discovery

    Kyiv, Ukraine, February 24 2021 - Enamine Ltd. a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments and screening compounds announced today that it has extended its long-standing research collaboration with Addex Therapeutics Ltd (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company specialized in allosteric modulation-based drug discovery and development. Enamine is providing Addex with its integrated capability in medicinal chemistry, pharmacology and ADME/PK (Absorption, Distribution, Metabolism, Excretion/Pharmacokinetics) to efficiently support Addex’ small molecule CNS drug discovery programs.

    Read press release

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Express Lead Library

Readily accessible lead-like libraries based on Enamine's latest core building blocks with unique underrepresented structures

5.82 M compounds

Express Lead Library (ELL) is an extension of REAL database focusing on novel screening compounds that can be synthesized from the most recently synthesized building blocks. Having the largest building block inventory Enamine continues its expansion. Each month it is enriched with 2,000 new functionalized compounds synthesized in-house. Many of them feature results of our latest research in medchem-driven organic synthesis. Following our doctrine of accelerating drug discovery it’s important to make such chemotypes available for biological screening as soon as possible. We have selected only unusual building blocks that contain at least 2 rings or 7-membered rings. They are called “core building blocks” as they bear essential molecular complexity rendering novelty to the enumerated compound libraries. All terms of REAL database including synthesis time of 3 weeks with at least 85% success rate are also valid for supplies from ELL. It is recommended as an abundant source of selected novel compounds in Compound Collection Enhancement programs and virtual screening projects.

  • 1 592 New building blocks synthesized in 2015-2017
  • Exclusivity. Over 90 % are offered on the market only by Enamine
  • Unique underrepresented structures. The selected building blocks have no close analogues in stock and have not been largely used for library synthesis: > 92 % have less than 25 derivatives in our stock screening collection
  • Essential molecular complexity. Fragment complexity > 600

ELL molecules

  • 5.82 Million new compounds
  • Lead-like physicochemical profiles: MW < 350, sLogP < 3.5 or MW < 400, sLogP < 3, rotatable bonds < 6 (no long chains, < 4 open-chain atoms), aromatic rings < 3 (at least one heteroaromatic)
  • Balanced diversity, no singletons: 107 572 Murcko frameworks, > 5 molecules/framework, 92 % has < 100 molecules/framework
  • No toxic or unwanted groups. Filters applied: PAINS, NO2, CN, ester, triflate, sulfoxide, open-chain sulfide, terminal alkyne, carbamate, Boc-, Fmoc-, aryl/alkyl bromide/iodide, aldehyde, 2-halo pyridine/pyrimidine, oxamides

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