More

Building Block Catalogue

225 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

14 Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2021

Recent News

  • 05 April 2021   News

    Open positions for Postdocs and Research Scientists

    We still have several funded Postdoc positions in organic chemistry to work at Enamine Ltd. (Ukraine, Kyiv) on a ERC-project “Saturated bioisosteres of benzene.”

    Start: any time.
    Please, send the application documents (motivation letter, CV, list of publications, recommendation letters) to Pavel.MykhailiukATmail.enamine.net

  • 01 March 2021   News

    Lumobiotics GmbH is part of an European consortial Project

    We are happy to announce the start of Project ALISE supported by European Commission under Horizon 2020 MSCA-RISE. As the coordinator of the Project, Enamine is involved in the development of light-controllable antibody peptide conjugates pushing the boundaries of photopharmacology towards clinical applications.

  • 24 February 2021   Press Releases

    Enamine extend collaboration with prominent Swiss Biotech

    A new multi-year drug discovery agreement will focus on CNS drug discovery

    Kyiv, Ukraine, February 24 2021 - Enamine Ltd. a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments and screening compounds announced today that it has extended its long-standing research collaboration with Addex Therapeutics Ltd (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company specialized in allosteric modulation-based drug discovery and development. Enamine is providing Addex with its integrated capability in medicinal chemistry, pharmacology and ADME/PK (Absorption, Distribution, Metabolism, Excretion/Pharmacokinetics) to efficiently support Addex’ small molecule CNS drug discovery programs.

    Read press release

Upcoming events

Discovery Diversity Sets

High-quality diverse library of latest compounds

10 240 and 50 240 compounds

The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Understanding of which compounds are desirable and which ones are to be avoided has been evolving rapidly over the last 15 years since introduction by Chris Lipinski his “Rule of 5”. The concepts of drug- and lead-likeness have been revised many times and complemented with MedChem refinement and PAINS exclusion filters. It was, however, commonly admitted that screening of the compound libraries designed using only appropriate molecular criteria does not guarantee identification of quality hits that can quickly and inexpensively furnish lead compounds. Researchers have begun to scrutinize selection of the compounds to screen. The screening libraries must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live” chemistry that can supply related chemical entities.

Only between 2014 and 2016 Enamine synthesized over 430 000 non-exclusive screening compounds, which feature our new diversity of Enamine-exclusive building blocks and scaffolds. Having the largest commercial screening collection in the world, Enamine remains the only library producer that keeps enhancing its collection with significant number of new compounds each year. The renowned Enamine quality of compounds has been distilled in the design of two Discovery Diversity Sets (DDS). They compose of 10 and 50 thousand highly diverse compounds produced only within last three years. Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three screening collections of Enamine – HTS, Advanced, and Premium. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds. They can be readily followed with analogues either from stock or from new syntheses. All building blocks are readily available from Enamine stock.

Key features

  • Novel compounds
  • No singletons, 3-5 compounds per cluster
  • 4 912 Bemis-Murcko frameworks (DDS 50)
  • No PAINS, only medchem friendly compounds
  • Express follow-up guaranteed

Comparative analysis of DDSs and commercially available compounds

74% of the compounds from DDS 10K and 70 % from DDS 50K are available exclusively at Enamine

Reference database of 16.8M commercially available compounds from 33 vendors were collected from Zinc and eMolecules.

Examples of the molecules

Z1885611703

Z1885611703
MW 358
ClogP 1.89

Z2017826378

Z2017826378
MW 302
ClogP 1.38

Z2060539340

Z2060539340
MW 307
ClogP 0.43

Z1647886734

Z1647886734
MW 273
ClogP 2.43

Z1683527071

Z1683527071
MW 298
ClogP 2.19

Z1640823403

Z1640823403
MW 325
ClogP 2.78

Z2054188929

Z2054188929
MW 342
ClogP 1.5

Z1727361122

Z1727361122
MW 275
ClogP 1.10

Z1461770453

Z1461770453
MW 338
ClogP 1.97

Z1846299521

Z1846299521
MW 316
ClogP 2.02

Z1265264308

Z1265264308
MW 346
ClogP 2.93

Z2053432847

Z2053432847
MW 261
ClogP 0.51

Z30996552

Z30996552
MW 362
ClogP 2.99

Z1850142310

Z1850142310
MW 301
ClogP 1.73

Molecular properties

DDS 10K

DDS 50K

Library Formats

Item
Catalog #
# of compounds
Amount
Plates and format

Item

1

Catalog #

DDS-10-Y-0

# of compounds

10 240

Amount

Assay-ready plates,
≤2 µL of 10 mM
DMSO solution

Plates and format

384-well, 320 cpds per plate:
first two and last two columns empty

Item

2

Catalog #

DDS-10-Z-0

# of compounds

10 240

Amount

Assay-ready plates,
≤2 µL of 10 mM
DMSO solution

Plates and format

1536-well plates, 1280 cpds per plate:
first two and last two columns empty

Item

3

Catalog #

DDS-10-Y-50

# of compounds

10 240

Amount

50 µL of 10 mM
DMSO solution

Plates and format

384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty

Item

4

Catalog #

DDS-10-X-100

# of compounds

10 240

Amount

100 µL of 10 mM
DMSO solution

Plates and format

96-well plates (Matrix Cat. No 4919),
80 cpds per plate: first and last columns empty

Item

5

Catalog #

DDS-50-Y-0

# of compounds

50 240

Amount

Assay-ready plates,
≤2 µL of 10 mM
DMSO solution

Plates and format

384-well plates, 320 cpds per plate:
first two and last two columns empty

Item

6

Catalog #

DDS-50-Z-0

# of compounds

50 240

Amount

Assay-ready plates,
≤2 µL of 10 mM
DMSO solution

Plates and format

1536-well plates, 1280 cpds per plate:
first two and last two columns empty

Item

7

Catalog #

DDS-50-Y-50

# of compounds

50 240

Amount

50 µL of 10 mM
DMSO solution

Plates and format

384-well plates (Matrix Cat. No 4312), 157 plates,
320 cpds per plate: first two and last two columns empty

Item

8

Catalog #

DDS-50-Y-100

# of compounds

50 240

Amount

100 µL of 10 mM
DMSO solution

Plates and format

96-well plates (Matrix Cat. No 4919), 628 plates,
80 cpds per plate: first and last columns empty

FOLLOW US

Contact us

I have read and agree with Privacy Policy of Enamine

Send me details