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Reach out to new chemical space breaking the availability bias:
11 000 000 000 molecules and beyond

REAL compounds

The world’s largest collection of building blocks in stock:
169 144 and counting

New Building Blocks

Run HTS directly at Enamine or have your copy from
Ever-expanding collection of 3 million compounds

Screening Libraries & HTS

120 000 Fragment compounds
including 10 000 covalent binders

Fragments

A broad test panel to support lead discovery
Integrated projects or a-la-carte service

ADME/T & in-vivo PK

Scientific research and development of techniques for the synthesis of organic compounds

High Fidelity Fragments

High Fidelity Library

Fragments of high MedChem tractability  

REAL Database

The largest enumerated database of synthetically feasible molecules

Functional Compounds

Impurity Reference Standards
 

Covalent Fragments

Covalent Fragments

Diverse covalent warheads with balanced reactivity

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from May 2019

Recent News

  • 26 March 2019   Press Releases

    Enamine extends multi-year drug discovery collaboration with Lundbeck

    Enamine and H. Lundbeck A/S (Lundbeck) announced the expansion of their research collaboration. Enamine will support Lundbeck’s in-house discovery chemistry competencies with three principal assets enabling Lundbeck to optimally identify and develop hit series in its multiple research programs. A large diverse library of 100 000 new screening compounds was done for hit finding activities on numerous therapeutic targets. Enamine’s make-on-demand REAL compounds are for efficient access to billions of novel chemical compounds. Enamine FTE increased dedicated team of chemists to effectively support Lundbeck on all hit related follow-up activities backed by immediate access to over 170 000 building blocks in Enamine’s inventory.

    Read press release

  • 12 February 2019   News

    Enamine to Support Large-scale Hit Discovery Programs via New ...

    Scientists at the UCSF, together with colleagues at the UNC, created the largest “docking-friendly” database of molecules, based on the Readily Accessible (REAL) compounds from Enamine. Practical validation of the new database was recently published in Nature magazine, demonstrating that it is capable of identifying extremely powerful and synthetically available new hits.

  • 05 February 2019   News

    Horizon 2020 Project PELICO, Coordinated by Enamine, Achieves Promising ...

    EU-funded project PELICO, under Enamine’s coordination, reports promising results in synthesis of peptides, their pharmacokinetic and toxicity studies, and coupling with photo-controlled building blocks to yield new photo-controlled peptidomimetics.

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Not many chemical reactions meet the stringent criteria to be selected for use in this emerging area. The reactions must be modular, wide in scope, proceed with high yields, stereospecific and biocompatible. Simple reaction conditions and simple isolation protocols are also of paramount importance. These criteria ensure generating substances quickly and reliably by joining together small reactive units, or building blocks. The biocompatibility opens the prospectives of in vivo reactions.

Among the reactions conforming to Click Chemistry requirements, three classes were identified: a) nucleophilic opening of strained electrophiles, for example, aziridines or epoxides; b) condensation reactions of aldehydes or ketones, for instance, formation of hydrazones and oximes; c) cycloaddition reactions.

One of the most useful is the reaction between organic azides and alkynes, calalysed by Cu(I) compounds. This reaction is a [3+2] cycloaddition which is highly specific, can be carried out in water, and fully bioorthogonal. As a result, it has rapidly established a prominent role in materials science, medicinal, and bioconjugation chemistry.

In the search for new drugs, the Click Chemistry started to give very promising results. For example, the very potent inhibitors 1-3 of various enzymes were discovered by the fragment approach made possible by the use of the appropriate linkers (highlighted in red), constructed by [3+2] azide-alkyne cycloaddition.

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Understanding the importance of the fast access to the diverse building blocks used in Click Chemistry, Enamine offers several collections of compounds providing access to many classes of organic fragments – heterocyclic rings, aromatic, heteroaromatic, aliphatic residues, functionalized by different functional groups. Recently we released set of Hydrazine Building Blocks suitable for Click Chemistry reactions. In this issue, we introduce the collection of azides, available from Enamine upon request, due to a limited shell life of these highly reactive compounds. Reliability of this offer is backed up by our vast experience in preparation of various fine chemicals and particularly azides. Examples of the most interesting azides available from Enamine are shown below.

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