Building Blocks Catalog

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Building Blocks

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from December 2022

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J. Org. Chem. 2011, 76 (14), 5774-5781

DOI: 10.1021/jo2008252

Ryabukhin S.; Naumchik V.; Plaskon A.; Grygorenko O.; Tolmachev A.

A general approach to 3-fluoro-, 3-chloro-, and 3-bromoquinolines which relies on organosilane-promoted Friedlander reaction of alpha-haloketones is described. The scope of the methylene component as well as influence of the organosilane component on the outcome of the reaction is studied. The method can be used under parallel synthesis conditions.

3-haloquinolines by Friedlander reaction of alpha-haloketones