Building Blocks Catalog

284 Thousand compounds in stock

Original and unique

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Building Blocks

210 Million novel building blocks

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Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

31B Billion REAL compounds and

Custom Library Synthesis

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On site access to all Enamine stock BB’s

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from October 2022

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Diversity Libraries

Product name
Description
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CLOUD

CLOUD-293

293 compounds

Description

Represents the diversity of structures and molecular targets of all FDA-approved chemical entities (Nat Chem Biol 13 (2017), 771–778)

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FDA approved drugs

FAD-1040

1 040 compounds

Description

Most relevant selection of drugs in one formulation/no duplicates. Contains WHO List of Essential Medicines including Lapatinib and latest approved drugs such as Tivozanib, etc.

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Bioactive Library

BRL-2320

2 320 compounds

Description

Actives with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs, steroids and molecular glues.

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Phenotypic Screening Library

PSL-5760

5 760 compounds

Description

Library of cell penetrating compounds and their closest analogs. Covers diverse therapeutic areas from antitumor, neurology and antibacterial to aging diseases.

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PAINS Library

PAINS-320

320 compounds

Description

Frequent hitters with most diverse scaffold selection – from small hydroquinone and other covalent modifiers to polyfluorinated highly lipophilic molecules and dyes.

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Focused Sets

Target / Therapeutic Area
Description
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Angiogenesis

184 compounds

Description

Angiogenesis related ligands targeting FLT3, DYRK1A, Collagenase 3, GAK, Bcr-Abl, BTK, EGFR etc.

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Apoptosis

38 compounds

Description

Apoptosis related ligands targeting Mdm2 Mcl-1 IAP Caspase Modulator I, Caspase 3 and Caspase 6, Bcl-2, p53, TNF-alpha.

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Cancer Immunology

390 compounds

Description

Molecules used for immune-oncology research targeting P2X3 receptor MAG lipase, PI3 kinase and P2Y12.

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Cell Cycle

94 compounds

Description

Сell cycle related compounds, e.g. LDC000067 CDK12-In-2 and Palbociclib selective and pan-CDK inhibitors, ROCK, mTOR and Aurora kinase inhibitors.

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Epigenetics

158 compounds

Description

Epigenetics related compounds targeting HDACs, HMT, JMJD, DNMT, Bromodomains, i KDM5 inhibitors and Sirtuin.

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GPCRs

738 compounds

Description

Bioactive GPCR-targeted molecules, including GPCR inhibitors, agonists, and allosteric modulators. Library represents actives against 195 unique GPCR targets.

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Growth Factors Cytokines

130 compounds

Description

Growth factors and cytokines ligands, including Ceritinib ALK inhibitor, Lucitanib VEGFR and FGFR inhibitor, MSX-127 CXCR4 antagonist, Eltrombopag Thrombopoietin receptor agonist etc.

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Ion Channels

300 compounds

Description

Ligands with annotated activity against 6 ion channel families and 105 unique targets. The library covers major applications typical for ion channel: cardiovascular regulation, neuroscience, immune response regulation.

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JAK-STAT

104 compounds

Description

JAK-STAT signalling targeted molecules, including Pazopanib multi-TK inhibitor, LY294002 TPK inhibitor, PF06700841 JAK1 inhibitor, SH-4-54 STAT3 inhibitor and other related actives.

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Kinases

366 compounds

Description

Kinase binders, including approved drugs Imatinib, covalent Ibrutinib, Dasatinib and highly active inhibitors of most important kinases such as RAF, MAPK, BTK and many other.

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Membrane Receptors

745 compounds

Description

Membrane receptors ligands, including Risperidone (5-HT2 receptor blocker, D2 receptor antagonist), VU0071063 (ATP-dependent potassium channel activator), CU-T12-9 (TLR1/2 antagonist), LY354740 (mGlu2/3 receptor agonist).

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Nuclear Hormone Receptors

160 compounds

Description

Nuclear receptor ligands with referenced activity against 368 unique molecular targets, including agonists Dienogest, antagonists Darolutamide, inverse antagonists GSK805.

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Protease Inhibitors

175 compounds

Description

High activity ligands against 104 human and pathogenic proteases, including Saxagliptin, anti-diabetic type 2 drug, Mpro SARS-CoV-2 inhibitors, Atazanavir HIV-1 protease inhibitor etc.

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Signal Transduction

254 compounds

Description

Signal transduction related ligands, including Selatinib EGFR/HER-2 inhibitor, XAV-939 Tankyrase1/2 inhibitor, STING agonist-1 G10, Fedratinib broad spectrum kinase inhibitor etc.

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Transporters

169 compounds

Description

Molecules with annotated activity against 12 transporter families and 82 unique targets, including Paroxetine (serotonin reuptake inhibitor), ML-352 (choline transporter 1 inhibitor, AR- C155858 (MCT1 and MCT2 inhibitor, GABA receptor ligands etc.

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Related products & services

Additionally we provide broad functionalization of Drugs and relative actives with covalent warheads, biotin or/and dye-linking, PED-derivatization and other modifications. Versatile chemistry and the largest stock of valuable reagents enables Enamine to produce new functionalization of well-known drugs.

We combined most diverse approaches and possible structural modifications to achieve most complete representation of our Target identification tools.

Enamine is a reliable partner for compound collection enhancement (CCE) programs providing a full cycle of services from development of the initial concept in close collaboration with customer and synthesis of the scaffolds to parallel chemistry and compound management of the library compounds.

We offer:

  • Business model adaptable for each customer – fee-for-service, FTE-based or mixed.
  • Flexible design – based on the customer’s template(s) or our own scaffold collection, or focused on special compound classes such as covalent ligands or macrocycles. We can reshape the compound collection using advanced chemoinformatics tools according to virtually any selection criteria.
  • Diversity and speed – we can rely on the world’s largest collection of stock Building Blocks (around 200K) to construct the target cores and to decorate them.
  • Experience – we are highly skilled in both parallel chemistry and complex multistep synthetic projects, with >2 000 customers varying from small biotech and academia to big pharma.
  • Quality control and logistics – we perform reversed-phase preparative HPLC purification on all synthesized compounds to assure they meet purity requirements (usually 90% or 95% pure). Their quality is controlled with LCMS and up to 100% with 1H NMR. The compounds can be delivered in virtually any containers, including those received from a customer and assay-ready plates for immediate screening.

Please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it. for more information and quotes on our service.

In 2007 Enamine Ltd and UORSY (Ukrorgsyntez Ltd) launched a joint project in order to establish a systematic chemically validated approach to synthesis of "in-stock-tomorrow" building blocks that consist of up to 21 heavy atoms and therefore can be used in medicinal chemistry and drug discovery. The average values for number of heavy atoms, MW and cLogP of the tangible building blocks are 18.3, 272 and 2.3, respectively. Full database (20 556 947 structures) and other relevant data including prices can be found at the library download page. The golden set of tangible building blocks (4 721 351 structures, containing up to 16 heavy atoms) have also been posted at Accelrys® Available Chemicals Directory. These databases are updated at least two times a year.

The main chemical classes of tangible building blocks are listed in the table below.

Type of Building Blocks Number of structures
Primary and Secondary Amines 4 484 000
Carboxylic Acids 1 009 000
Amino Acids 191 000
Alkylating and Arylating Agents 679 000
Sulfonyl Chlorides 26 000
Aldehydes and Ketones 317 000
Alkyl- and Arylhydrazines 43 000
Alcohols 852 000
Phenols 135 000
Thiols 27 000
Amidoximes and Amidines 118 000
Aryl bromides and Aryl iodides 743 000
Boronic acids 7 000
Alkyl- and Arylazides 7 600
Terminal acetylenes 34 000

Rigorously validated chemical procedures ensure high feasibility and cost effectiveness of tangible building blocks and fragments. About 8 500 building blocks were synthesized in 2009 with lead time of 4-6 weeks and feasibility of 80%.  Over 4 000 of these compounds were selected from the database of tangible building blocks and ordered by pharma and biotech companies worldwide at fixed prices ranging from 200 to 800 € per gram. Weekly progress reports on the synthesis of the ordered tangible building blocks and fragments are provided to the customers.

J. Org. Chem. 2011, 76 (14), 5774-5781

DOI: 10.1021/jo2008252

Ryabukhin S.; Naumchik V.; Plaskon A.; Grygorenko O.; Tolmachev A.

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